Document Detail

Effect of lidocaine on the ventilatory and airway responses to exercise in asthmatics.
MedLine Citation:
PMID:  7458056     Owner:  NLM     Status:  MEDLINE    
An aerosol of 4% lidocaine was delivered during the last third of inspiration to patients with bronchial asthma while they were quietly breathing. After this procedure, both cough reflex (inhalation of 10% citric acid) and gag reflex (mechanical irritation of the larynx) were absent in all patients for 15 to 20 min. This type of anesthesia was tolerated well by all patients, and did not significantly influence baseline pulmonary function tests. On another day, this procedure was used prior to treadmill exercise testing. Anesthesia blocked the development of exercise-induced bronchoconstriction (EIB) after the exercise period, as measured by FEV1, FEF25-75%, Vmax70% TLC, and specific airway conductance (SGaw). It was also found that the degree of minute ventilation (VE), as measured during exercise with airway anesthesia, significantly decreased (p < 0.01) compared with VE measured during exercise without lidocaine. The results suggested that local anesthesia of the upper and large airways in patients with bronchial asthma can significantly inhibit EIB and significantly decrease VE during moderate exercise. It can be postulated that mucosal receptors in the upper and large airways are directly involved in the initiation of EIB, and that their stimulation may be responsible for increased ventilation during exercise.
P L Enright; J F McNally; J F Souhrada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  122     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1980 Dec 
Date Detail:
Created Date:  1981-03-24     Completed Date:  1981-03-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  823-8     Citation Subset:  AIM; IM    
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MeSH Terms
Airway Resistance
Asthma / physiopathology*
Lidocaine / pharmacology*
Lung / physiopathology*
Lung Volume Measurements
Physical Exertion*
Respiration / drug effects*
Reg. No./Substance:

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