| Effect of lidocaine on neutrophil chemotaxis in newborn infants. | |
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MedLine Citation:
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PMID: 9624580 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Anesthetic drugs can influence the immune system, particularly granulocyte function. The goal of the present study was to evaluate if lidocaine used for epidural anesthesia during cesarean section can influence neonatal neutrophil chemotaxis. We measured chemotaxis and plasma cord lidocaine and cortisol levels in (A) 15 infants born by cesarean section with epidural anesthesia, (B) 15 infants born by vaginal delivery, and (C) 20 infants born by cesarean section with general anesthesia. Chemotaxis levels were significantly lower in group A infants (35.5 +/- 16.1 microns) compared to groups B (54.6 +/- 10.5 microns) and C (71.4 +/- 23 microns). The highest cortisol levels were observed in vaginally delivered infants. A significant inverse relationship was observed between chemotaxis and lidocaine levels (r = -0.6, P = 0.016) in infants born by cesarean section after epidural anesthesia, while no significant correlation was observed between chemotaxis and cortisol level. In conclusion, lidocaine, transferred through the placenta to the fetus during epidural anesthesia, may have an inhibitory effect on chemotaxis. |
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Authors:
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A Gasparoni; D De Amici; L Ciardelli; M Autelli; M Regazzi-Bonora; A Bartoli; G Chirico; G Rondini |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical immunology Volume: 18 ISSN: 0271-9142 ISO Abbreviation: J. Clin. Immunol. Publication Date: 1998 May |
Date Detail:
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Created Date: 1998-08-26 Completed Date: 1998-08-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8102137 Medline TA: J Clin Immunol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 210-3 Citation Subset: IM |
Affiliation:
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Research Laboratory (Paediatric Oncohaematology), Policlinico San Matteo-IRCCS, Pavia, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia, Epidural Anesthesia, Obstetrical Anesthetics, Local / blood, pharmacology* Cesarean Section Chemotaxis, Leukocyte / drug effects* Fetal Blood / cytology, metabolism Humans Hydrocortisone / blood Infant, Newborn Leukocyte Count Lidocaine / blood, pharmacology* Neutrophils / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Local; 137-58-6/Lidocaine; 50-23-7/Hydrocortisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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