Document Detail

Effect of lidocaine on neutrophil chemotaxis in newborn infants.
MedLine Citation:
PMID:  9624580     Owner:  NLM     Status:  MEDLINE    
Anesthetic drugs can influence the immune system, particularly granulocyte function. The goal of the present study was to evaluate if lidocaine used for epidural anesthesia during cesarean section can influence neonatal neutrophil chemotaxis. We measured chemotaxis and plasma cord lidocaine and cortisol levels in (A) 15 infants born by cesarean section with epidural anesthesia, (B) 15 infants born by vaginal delivery, and (C) 20 infants born by cesarean section with general anesthesia. Chemotaxis levels were significantly lower in group A infants (35.5 +/- 16.1 microns) compared to groups B (54.6 +/- 10.5 microns) and C (71.4 +/- 23 microns). The highest cortisol levels were observed in vaginally delivered infants. A significant inverse relationship was observed between chemotaxis and lidocaine levels (r = -0.6, P = 0.016) in infants born by cesarean section after epidural anesthesia, while no significant correlation was observed between chemotaxis and cortisol level. In conclusion, lidocaine, transferred through the placenta to the fetus during epidural anesthesia, may have an inhibitory effect on chemotaxis.
A Gasparoni; D De Amici; L Ciardelli; M Autelli; M Regazzi-Bonora; A Bartoli; G Chirico; G Rondini
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical immunology     Volume:  18     ISSN:  0271-9142     ISO Abbreviation:  J. Clin. Immunol.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-08-26     Completed Date:  1998-08-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8102137     Medline TA:  J Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  210-3     Citation Subset:  IM    
Research Laboratory (Paediatric Oncohaematology), Policlinico San Matteo-IRCCS, Pavia, Italy.
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MeSH Terms
Anesthesia, Epidural
Anesthesia, Obstetrical
Anesthetics, Local / blood,  pharmacology*
Cesarean Section
Chemotaxis, Leukocyte / drug effects*
Fetal Blood / cytology,  metabolism
Hydrocortisone / blood
Infant, Newborn
Leukocyte Count
Lidocaine / blood,  pharmacology*
Neutrophils / drug effects*
Reg. No./Substance:
0/Anesthetics, Local; 137-58-6/Lidocaine; 50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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