| Effect of lidocaine on escape rate in patients with complete atrioventricular block: B. Proximal His bundle block. | |
| | |
MedLine Citation:
|
PMID: 7234706 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Lidocaine was administered intravenously (a loading dose of 1.5 mg/kg body weight followed by a 3 mg/min infusion) to 10 patients with complete atrioventricular (A-V) block proximal to the His bundle and A-V junctional escape rhythm. A-V block was not due to an acute myocardial infarction in seven patients (group I) and was due to an acute inferior wall infarction in three patients (group II). Lidocaine had either no or only a slight depressant effect on the rate of the escape pacemaker in patients in group I but caused severe bradycardia or asystole in two of three patients in group II. Lidocaine had no consistent effect on the atrial rate and did not change the QRS duration and H-V intervals in any patient. These observations are consistent with the results of animal studies that showed that lidocaine selectively depressed conduction in ischemic or depolarized myocardium. The findings also suggest that the use of lidocaine without prior insertion of a pacemaker is unsafe in patients with acute myocardial infarction and complete A-V block proximal to the His bundle. |
| | |
Authors:
|
C S Kuo; C P Reddy |
Related Documents
:
|
4028346 - Reentrant ventricular arrhythmias in the late myocardial infarction period in the dog. ... 8947796 - Interpretation of the emergency electrocardiogram by junior hospital doctors. 16327066 - Correlation between 25 element contents in mane hair in riding horses and atrioventricu... 624316 - The electrocardiographic diagnosis of left septal fascicular block. 9225796 - Adenosine coronary vasodilation in coronary artery disease: technetium-99m tetrofosmin ... 22307676 - Bariatric surgery to unload the stressed heart: a metabolic hypothesis. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The American journal of cardiology Volume: 47 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1981 Jun |
Date Detail:
|
Created Date: 1981-07-20 Completed Date: 1981-07-20 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1315-20 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Bundle of His / physiopathology* Electrocardiography Female Heart Block / drug therapy* Heart Conduction System / physiopathology* Humans Lidocaine / adverse effects, blood, therapeutic use* Male Middle Aged Pacemaker, Artificial* |
| Chemical | |
Reg. No./Substance:
|
137-58-6/Lidocaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Procainamide-induced polymorphous ventricular tachycardia.
Next Document: Effects of supplementation of the diets with calcium and calcium-rich foods on bone density of elder...