| Effect of levothyroxine on total lipid profiles as assessed by analytical capillary isotachophoresis in a patient with hypothyroidism. | |
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MedLine Citation:
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PMID: 17001111 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The patient was a 51-year-old Japanese female who had been diagnosed with hyperlipidemia. At the first medical examination, her serum levels of total cholesterol (TC) and triglyceride (TG) were 482 and 205 mg/dl, respectively. Since hyperlipidemia was not improved by pravastatin, atorvastatin or niceritrol, and since the levels of thyroid-stimulating hormone (TSH) and free T4 were 730 IU/ml and 0.3 ng/dl, respectively, the patient was diagnosed as secondary hyperlipidemia with hypothyroidism. A method for the charge isolation of lipoproteins using capillary isotachophoresis (cITP) is proposed as a clinical application because it allows us to quantitatively measure electronegative low-density lipoprotein cholesterol (LDL-C), a potent marker of coronary heart disease. After 5 months of treatment with levothyroxine, Serum TC and LDL-C levels drastically decreased without statin treatment and high-density lipoprotein cholesterol (HDL-C) increased. In the lipoprotein profiles as assessed by cITP after treatment with levothyroxin, all HDL-C subfractions were increased and fast-migrating LDL/electronegative LDL appeared to be greatly reduced after treatment, while the area under the non-modified LDL peak was increased. The cITP analysis was able to obtain more information about coronary risk factors and may be clinically useful for evaluating the effect of treatment with levothyroxine in patients with hypothyroidism and secondary hyperlipidemia. |
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Authors:
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Yoshihiro Kiya; Shin-ichiro Miura; Bo Zhang; Hidenori Urata; Keijiro Saku |
Publication Detail:
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Type: Case Reports; Journal Article Date: 2006-09-26 |
Journal Detail:
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Title: Endocrine journal Volume: 53 ISSN: 0918-8959 ISO Abbreviation: Endocr. J. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-12-28 Completed Date: 2007-04-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9313485 Medline TA: Endocr J Country: Japan |
Other Details:
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Languages: eng Pagination: 865-8 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Fukuoka University School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Electrophoresis, Capillary Female Humans Hyperlipidemias / blood, drug therapy*, etiology Hypothyroidism / blood*, complications, drug therapy Lipids / blood* Lipoproteins / blood Middle Aged Thyroxine / pharmacology*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Lipids; 0/Lipoproteins; 7488-70-2/Thyroxine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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