Document Detail

Effect of levothyroxine replacement therapy on paraoxonase-1 and carotid intima-media thickness in subclinical hypothyroidism.
MedLine Citation:
PMID:  20037493     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Paraoxonase-1 (PON-1) may play an important role in atherosclerosis. Atherosclerosis is an inflammatory disease and C-reactive protein is a marker for inflammation. The aim of this study was to determine serum PON-1 activity and high-sensitivity C-reactive protein (hs-CRP) levels and assess carotid intima-media thickness, a marker of early atherosclerotic changes, in patients with subclinical hypothyroidism. MATERIAL/METHODS: hs-CRP concentrations and PON-1 activity with respect to carotid intima-media thickness were evaluated in 38 subclinical hypothyroidism patients (normolipidemic, mean age: 49.79+/-10.04 years) before and after 3 months of stable euthyroidism and compared with those of 19 euthyroid normolipidemic healthy individuals (mean age: 49.95+/-8.12 years). RESULTS: At baseline, the patients with subclinical hypothyroidism had similar levels of PON-1 activity and hs-CRP and a similar lipid profile as the controls; however, the carotid intima-media thickness was greater than in the controls. Levothyroxine treatment had no effect on serum PON-1 activity and hs-CRP level, but it resulted in a significant reduction in carotid intima-media thickness in the subclinical hypothyroidism patients. CONCLUSIONS: PON-1 activity and hs-CRP levels did not significantly differ between subclinical hypothyroid patients and controls. Although levothyroxine treatment might have the potential to reverse the progression of atherosclerosis in subclinical hypothyroid patients, PON-1 activity and hs-CRP levels were not affected by this treatment. The reduction in carotid intima-media thickness was independent of the decrease in serum lipid profile or other variables.
Levent Kebapcilar; Abdurrahman Comlekci; Pinar Tuncel; Ahmet Solak; Mustafa Secil; Omur Gencel; Mustafa Sahin; Ismail Sari; Sena Yesil
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medical science monitor : international medical journal of experimental and clinical research     Volume:  16     ISSN:  1643-3750     ISO Abbreviation:  Med. Sci. Monit.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-28     Completed Date:  2010-03-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9609063     Medline TA:  Med Sci Monit     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  CR41-7     Citation Subset:  IM    
Department of Internal Medicine, Dokuz Eylul University, Izmir, Turkey.
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MeSH Terms
Aryldialkylphosphatase / blood*
Blood Chemical Analysis
Body Mass Index
Body Weights and Measures
C-Reactive Protein / metabolism*
Carotid Arteries / ultrasonography
Hormone Replacement Therapy / methods*
Hypothyroidism / blood,  drug therapy*,  enzymology,  pathology
Middle Aged
Statistics, Nonparametric
Tunica Intima / pathology*
Reg. No./Substance:
7488-70-2/Thyroxine; 9007-41-4/C-Reactive Protein; EC

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