Document Detail


Effect of the levonorgestrel intrauterine device on genital HIV-1 RNA shedding among HIV-1-infected women not taking antiretroviral therapy in Nairobi, Kenya.
MedLine Citation:
PMID:  23446496     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of the levonorgestrel-releasing intrauterine device (LNG-IUD) on genital HIV-1 RNA shedding and inflammation among 25 HIV-infected women was evaluated. Blood, endocervical, and cervicovaginal lavage samples were collected from HIV-infected women not taking antiretrovirals before LNG-IUD insertion and 1 month, 3 month, and 6 months thereafter. HIV-1 RNA was quantitated by real-time reverse transcriptase-polymerase chain reaction. Inflammatory markers were measured by enzyme immunoassay. Genital HIV-1 RNA shedding and inflammatory markers did not differ between LNG-IUD placement and month 6, with the exception of interleukin 1β that increased (0.42 log10; 95% confidence interval: 0.10 to 0.75). The LNG-IUD did not increase genital HIV-1 RNA shedding after 6 months of use.
Authors:
Jenell S Coleman; Christina Mwachari; Jennifer Balkus; Lucy Sanguli; Angela Muliro; Kathy Agnew; Robert W Coombs; Craig R Cohen; Jane Hitti
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of acquired immune deficiency syndromes (1999)     Volume:  63     ISSN:  1944-7884     ISO Abbreviation:  J. Acquir. Immune Defic. Syndr.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-13     Completed Date:  2013-07-08     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  100892005     Medline TA:  J Acquir Immune Defic Syndr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  245-8     Citation Subset:  IM; X    
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MeSH Terms
Descriptor/Qualifier:
Adult
Anti-Retroviral Agents / therapeutic use
CD4 Lymphocyte Count
Cervix Uteri
Contraceptive Agents, Female / therapeutic use
Female
HIV Infections
HIV-1 / drug effects,  genetics
Humans
Interleukin-1beta / blood
Intrauterine Devices, Medicated*
Kenya
Levonorgestrel / therapeutic use*
RNA, Viral / analysis*,  blood*
Vaginal Douching
Grant Support
ID/Acronym/Agency:
AI-38858/AI/NIAID NIH HHS; HD-40540/HD/NICHD NIH HHS; P01 HD040540/HD/NICHD NIH HHS; P30 AI-27757/AI/NIAID NIH HHS; P30 AI027757/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Retroviral Agents; 0/Contraceptive Agents, Female; 0/Interleukin-1beta; 0/RNA, Viral; 5W7SIA7YZW/Levonorgestrel
Comments/Corrections

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