Document Detail


Effect of levetiracetam on cognitive functions and quality of life: a one-year follow-up study.
MedLine Citation:
PMID:  19017572     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The purpose of the study was to assess changes in cognitive functions and quality of life in patients with epilepsy over one year of treatment with levetiracetam (LEV) as add-on therapy. METHODS: Thirty-two patients (16 women; 16 men) who received LEV as an add-on treatment were included, and 27 completed the one-year follow-up period. Extensive neuropsychological assessments, together with a quality-of-life questionnaire were administered at baseline and at one, three, six and twelve months after beginning the add-on treatment. Patients received LEV starting with 500 mg/day in the first week, increasing by a further 500 mg/day per week until a target dose of 2 000 mg/day was reached by the end of the first month. RESULTS: At the one-year follow-up, a significant improvement was observed in measurements of prospective memory, working memory, motor functions, verbal fluency, attention and quality of life. Performance for neuropsychological and quality-of-life tests was not affected by external variables such as seizure reduction or changes in previous anti-epileptic treatment. Slight changes between patients were observed, but these were not clinically significant.The limited sample size and the lack of a control group should be mentioned as limitations of the study. No control group was evaluated as in our clinical practice it was difficult to establish a comparable group of patients. Changes in the different variables were assessed by comparing baseline information with follow-up results.Despite the study limitations, we consider that the one-year treatment period provides valuable information regarding the drug's long-term effects in this setting. CONCLUSIONS: Results of the present study suggest that long-term LEV treatment as add-on therapy does not interfere with cognitive function and improves quality of life.
Authors:
Mariana López-Góngora; Alejandro Martínez-Domeño; Carmen García; Antonio Escartín
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Epileptic disorders : international epilepsy journal with videotape     Volume:  10     ISSN:  1294-9361     ISO Abbreviation:  Epileptic Disord     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-21     Completed Date:  2009-01-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100891853     Medline TA:  Epileptic Disord     Country:  France    
Other Details:
Languages:  eng     Pagination:  297-305     Citation Subset:  IM    
Affiliation:
Department of Neurology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona Spain. mlopezgon@santpau.cat
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anticonvulsants / adverse effects*,  therapeutic use*
Cognition / drug effects*
Epilepsy / drug therapy*,  psychology*
Female
Follow-Up Studies
Humans
Male
Middle Aged
Neuropsychological Tests
Piracetam / adverse effects,  analogs & derivatives*,  therapeutic use
Prospective Studies
Quality of Life
Seizures / epidemiology
Young Adult
Chemical
Reg. No./Substance:
0/Anticonvulsants; 33996-58-6/etiracetam; 7491-74-9/Piracetam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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