| Effect of levamisole on lymphocyte blastogenesis and neutrophil function in dexamethasone-treated cattle. | |
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MedLine Citation:
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PMID: 6093649 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Levamisole was evaluated at 6 dose levels for its ability to prevent the dexamethasone-induced suppression of in vitro lymphocyte blastogenesis or neutrophil function in cattle. Dexamethasone (0.4 mg/kg of body weight, IM) and levamisole hydrochloride (0.5, 1.0, 2.0, 4.0, or 8.0 mg/kg orally) were administered to groups of 4 cattle daily for 3 days. Another group of 4 cattle were given the 3-day dexamethasone treatment and 6.0 mg/kg of levamisole (the recommended anthelmintic dose) was given only once on the 1st day that dexamethasone was given. Results obtained from the dexamethasone-levamisole-treated cattle were compared with results obtained from cattle that were given only dexamethasone. Levamisole had no apparent consistent ability to enhance lymphocyte blastogenic responsiveness (to the mitogens phytohemagglutinin, concanavalin A, or pokeweed mitogen or in a 1-way mixed lymphocyte reaction) or to enhance neutrophil function (random migration, nitroblue tetrazolium reduction, iodination, or antibody-dependent cell-mediated cytotoxicity) in dexamethasone-treated cattle. |
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Authors:
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J A Roth; M L Kaeberle |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: American journal of veterinary research Volume: 45 ISSN: 0002-9645 ISO Abbreviation: Am. J. Vet. Res. Publication Date: 1984 Sep |
Date Detail:
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Created Date: 1984-12-06 Completed Date: 1984-12-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375011 Medline TA: Am J Vet Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1781-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
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pharmacology Animals Antibody-Dependent Cell Cytotoxicity / drug effects Cattle / immunology* Cell Migration Inhibition Dexamethasone / antagonists & inhibitors, pharmacology Immune Tolerance / drug effects Levamisole / administration & dosage, pharmacology* Lymphocyte Activation / drug effects* Male Mitogens / pharmacology Neutrophils / drug effects*, immunology |
| Chemical | |
Reg. No./Substance:
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0/Mitogens; 14769-73-4/Levamisole; 50-02-2/Dexamethasone; 9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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