| Effect of leukotrienes B4, C4, and D4 on segmental pulmonary vascular pressures. | |
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MedLine Citation:
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PMID: 2537284 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Leukotrienes (LTs) C4 and D4 are vasoconstrictors and are thought to increase both systemic and pulmonary vascular permeability. However, we and others have observed that LTC4 and LTD4 cause pulmonary vasoconstriction but do not increase the fluid filtration coefficient of excised guinea pig lungs perfused with a cell-depleted perfusate. To determine what vascular segments were exposed to an LT-induced increase in intravascular hydrostatic pressure we measured pulmonary arterial (Ppa), pulmonary arterial occlusion (Po,a), venous (Po,v) and double occlusion (Pdo) pressures in isolated guinea pig lungs perfused with a cell-depleted buffered salt solution before and after injecting 4 micrograms of LTB4, LTC4, or LTD4 into the pulmonary artery. All three LTs increased airway pressures and also increased Ppa, Po,a, and Pdo. Histamine (15 micrograms) as well as serotonin (20 or 200 micrograms) had the same effect. In excised rabbit lungs, histamine and serotonin increased only Ppa, and Po,a. LTC4 had no vasoactivity. There are marked species variations with regard to the activity and site of action of histamine, serotonin, and LTC4 on the pulmonary circulation. |
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Authors:
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R K Albert; W J Lamm; W R Henderson; R W Bolin |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 66 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1989 Jan |
Date Detail:
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Created Date: 1989-04-06 Completed Date: 1989-04-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 458-64 Citation Subset: IM |
Affiliation:
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Veterans Administration Medical Center, Seattle, Washington. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Guinea Pigs Histamine / pharmacology Hydrostatic Pressure Leukotriene B4 / pharmacology* Microcirculation / drug effects Perfusion Pulmonary Circulation / drug effects* Rabbits SRS-A / pharmacology* Thromboxane B2 / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/SRS-A; 51-45-6/Histamine; 54397-85-2/Thromboxane B2; 71160-24-2/Leukotriene B4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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