Document Detail

Effect of length of gestation on maternal cellular immunity to human trophoblast antigens.
MedLine Citation:
PMID:  984088     Owner:  NLM     Status:  MEDLINE    
Maternal lymphocyte reactivity to human trophoblast antigens was studied in placentas of gestational ages 8 to 14 weeks and 32 to 34 weeks, respectively. Significant trophoblast lysis became apparent after 24 hours' incubation in the latter case compared with a time lag of 72 hours in the terminated gestations. Maternal cellular immunity, therefore, was not detected during the first 3 1/2 months of pregnancy, but was detectable by the time of parturition. The possible significance is discussed with respect to the antigenic stimulus and survival of the fetal allograft.
P V Taylor; G Gowland; K W Hancock; J S Scott
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  125     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1976 Jun 
Date Detail:
Created Date:  1976-12-23     Completed Date:  1976-12-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  528-31     Citation Subset:  AIM; IM    
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MeSH Terms
Antilymphocyte Serum
Cytotoxicity Tests, Immunologic
Gestational Age*
Immunity, Cellular*
Lymphocytes / immunology
Maternal-Fetal Exchange
Placenta / immunology
Trophoblasts / immunology*
Reg. No./Substance:
0/Antigens; 0/Antilymphocyte Serum

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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