Document Detail

Effect of length changes on bronchial diameters.
MedLine Citation:
PMID:  7263377     Owner:  NLM     Status:  MEDLINE    
The effect of physiological changes in length on the pressure-diameter (PD) behavior of large, excised, intrapulmonary pig, dog, and human bronchi was studied. Length changes did not alter PD behavior of pig bronchi. Lengthening reduced the diameter of dog bronchi but did not alter the shape of the PD curve. In humans, lengthening reduced the diameter at high transmural pressures but not at zero transmural pressure. The wave-speed theory of flow limitation was used as a first approximation to estimate the effect of the length-induced changes on maximal expiratory flow (Vmax). Use of the usual in situ (parenchyma intact) PD curve would lead to a 16% overestimation of Vmax at 45% total lung capacity (TLC) in dog and to a 17% underestimation at 64% TLC in humans. The effect in humans was age dependent and was most pronounced in subjects more than 40 yr of age.
R E Hyatt; K P Offord; S J Lai-Fook
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology: respiratory, environmental and exercise physiology     Volume:  50     ISSN:  0161-7567     ISO Abbreviation:  J Appl Physiol Respir Environ Exerc Physiol     Publication Date:  1981 Jun 
Date Detail:
Created Date:  1981-10-25     Completed Date:  1981-10-25     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  7801242     Medline TA:  J Appl Physiol Respir Environ Exerc Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1168-72     Citation Subset:  IM    
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MeSH Terms
Bronchi / anatomy & histology,  physiology*
Species Specificity
Swine / physiology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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