Document Detail


Effect of left ventricular--to--aortic bypass on infarct size and infarct microcirculation in baboons.
MedLine Citation:
PMID:  7464204     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A major diagonal branch of the left anterior descending coronary artery (LAD) was acutely occluded in 17 baboons. Complete left ventricular (LV) decompression was achieved with a left heart bypass (LHB) system in six baboons while 11 baboons served as untreated controls. In the treated group, LHB was initiated after 30 minutes of coronary occlusion. For a period of 6 hours after occlusion, aortic pressure, LV pressure, left atrial pressure, and cardiac output were monitored. During the same monitoring period, electrograms were recorded from a high resolution matrix of fixed epicardial electrodes. Regional myocardial blood flow was determined prior to and at intervals following the initiation of LHB with radioactive microspheres. Infarct size was assessed histologically from serial cross sections of the left ventricle. The degree of salvage achieved by LHB was assessed by comparing the epicardial area of infarction 6 hours after occlusion (AI) to the area of epicardial St-segment elevation (STE) 30 minutes after occlusion (maxAST). In the LHB-treated group, 40.0% +/- 8.1% (SEM) of maxAST showed subsequent infarction; in the control group, 79.8% +/- 2.7% of maxAST showed eventual infarction (p less than 0.01). STE overlying the region of ischemia in the LHB-treated group did not undergo the spontaneous decline observed in the control group, which is normally associated with the progression of necrosis. Regional myocardial blood flow did not change significantly in the ischemic region during the period of occlusion following LHB. LHB. The results suggest that LHB is capable of substantial salvage of acutely ischemic myocardium by reducing myocardial work and thus reducing myocardial oxygen requirements.
Authors:
W Ruf; G T Smith; G Geary; V Pressler; R J Anema; A Suehiro; J J McNamara
Related Documents :
22254214 - Aldosterone and aldosterone antagonists in cardiac disease: what is known, what is new.
1682484 - Cardiac effects of beta-2 adrenoceptor stimulation with intracoronary procaterol in the...
3565594 - Effect of aortic constriction on the functional border zone.
2601004 - Infarct sizing after reperfusion by two-dimensional echocardiography and serum cardiac ...
8146634 - Cold climate is an important factor in explaining regional differences in coronary mort...
8641024 - Coronary plaque erosion without rupture into a lipid core. a frequent cause of coronary...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  81     ISSN:  0022-5223     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  1981 Mar 
Date Detail:
Created Date:  1981-04-24     Completed Date:  1981-04-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  408-18     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Aorta, Thoracic / surgery*
Assisted Circulation / methods
Coronary Circulation
Electrocardiography
Heart Ventricles / surgery*
Hemodynamics
Myocardial Infarction / pathology,  surgery*
Papio
Regional Blood Flow
Grant Support
ID/Acronym/Agency:
2R01 HL 14571-07/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Leg wound complications associated with coronary revascularization.
Next Document:  Importance of edema and compliance changes during 24 hours of preservation of the dog heart.