Document Detail

Effect of left ventricular assist device on circulatory autonomic nervous activity.
MedLine Citation:
PMID:  15112890     Owner:  NLM     Status:  MEDLINE    
PURPOSE: For evaluation of the autonomic nervous system (ANS) activity of patients with mechanical circulatory support including LVAD, IABP and PCPS, arterial pressure variability (APV) was examined. APV is the power density values of pressure signals. High frequency (0.15 to 0.4 Hz) and low frequency (0.04 to 0.15 Hz) components of APV are regarded as a function of the autonomic nervous system. METHODS: Arterial pressure signals were acquired every 2 hours at 100 Hz for 6 minutes. Power spectral analysis was carried out, and APV was observed in 18 patients with IABP and/or PCPS. APV was also observed in 3 patients with LVADs (Xemex, Zeon Medical, Japan) before their discharge from ICU for transfer to another hospital for cardiac transplantation. RESULTS: Although the value gradually increased in 18 patients with IABP and/or PCPS, sustained low values of LFAnorm of APV in 6 patients were related to prolonged mechanical support, and 4 patients among them died consequently. The normalized power spectral component with low frequency (LFAnorm) was maintained at relatively high values in 3 patients with LVADs. CONCLUSION: The study results suggest that power spectral analysis of systemic arterial pressure offers a reasonable means for the evaluation of the severity of patient cardiovascular condition and for the prediction of clinical outcome. It also suggested that LVAD support exerts a favorable effect on ANS in patients with severe heart failure before cardiac transplantation.
T Tsutsui; R Takiya; T Jikuya; O Shigeta; Y Sakakibara; Y Sankai
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The International journal of artificial organs     Volume:  27     ISSN:  0391-3988     ISO Abbreviation:  Int J Artif Organs     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-04-28     Completed Date:  2004-07-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7802649     Medline TA:  Int J Artif Organs     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  243-50     Citation Subset:  IM    
Department of Critical Care Medicine, Institute of Clinical Medicine, University of Tsukuba, Japan.
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MeSH Terms
Autonomic Nervous System / physiopathology*
Blood Circulation / physiology*
Blood Pressure
Heart Failure / physiopathology,  therapy
Heart-Assist Devices*
Middle Aged
Treatment Outcome

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