Document Detail

Effect of lectin from the ascidian on the growth and the adhesion of HeLa cells.
MedLine Citation:
PMID:  11506176     Owner:  NLM     Status:  MEDLINE    
Cell adhesion molecules, some of which are lectins, play a key role in the control of normal and pathological processes of various living organisms. We found herein that N-acetyl-D-glucosamine-specific lectin, isolated from the ascidian Didemnum ternatanum (DTL), alters the growth properties of HeLa tumor cells depending on the anchorage. DTL was shown to increase the proliferation of HeLa cells grown in soft agar greatly (in anchorage-independent fashion). In contrast, DTL inhibits the proliferative activity of HeLa cells grown on solid substrate and acts as inductor of differentiation, slowing cell growth, increasing the cell attachment and spreading. Scanning electron microscopic data have demonstrated that DTL treatment resulted in pronounced changes of the shape and surface of HeLa cells. Changes of cellular morphology correlated with essential redistribution of actin microfilaments.
N A Odintsova; N I Belogortseva; A V Khomenko; I V Chikalovets; P A Luk'yanov
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  221     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-08-16     Completed Date:  2002-02-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  133-8     Citation Subset:  IM    
Laboratory of Cell Biophysics, Institute of Marine Biology, Far East Branch of RAS, Vladivostok, Russia.
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MeSH Terms
Actins / metabolism
Agar / chemistry
Cell Adhesion / drug effects*
Cell Differentiation / drug effects
Cell Division / drug effects
Cell Size / drug effects
Clone Cells
Collagen / metabolism
Cytoskeleton / drug effects,  ultrastructure
Dose-Response Relationship, Drug
Hela Cells
Lectins / metabolism,  pharmacology*
Microfilaments / drug effects,  ultrastructure
Microscopy, Electron, Scanning
Reg. No./Substance:
0/Actins; 0/Lectins; 9002-18-0/Agar; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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