Document Detail


Effect of the leafy vegetable Solanum nigrum on the activities of some liver drug-metabolizing enzymes after aflatoxin B1 treatment in female rats.
MedLine Citation:
PMID:  1900029     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Wistar albino female rats were maintained for 10 d on diets containing various levels of the vegetable Solanum nigrum. Simultaneously, they received daily intraperitoneal injections of aflatoxin B1 (AFB1) (either 0.2 or 0.4 mg/kg body-weight) diluted in propylene glycol. At the end of the experiment, all animals were killed and their serum and hepatic microsomes were prepared for assay of enzymes. Results showed that aminopyrine N-demethylase activity increased 2.5-fold with 200 (S200) and 600 (S600) g S. nigrum/kg diets. Activity of uridine diphosphate glucuronyltransferase (UDPGT) (EC 2.4.1.17) also increased twofold. Similar results were obtained with glutathione S-transferase (EC 2.5.1.18) activity which increased by 60% with diet S600. After AFB1 treatment, a general increase in the activities of the above enzymes was found, except for UDPGT in the group fed on diet S600. When rats were fed on the diet without S. nigrum, AFB1 induced an increase in alkaline phosphatase (ALP) (EC 3.1.3.1), aspartate aminotransferase (AST) (EC 2.6.1.1) and gamma-glutamyltransferase (gamma-GT) (EC 2.3.2.2) levels in the serum. AFB1 also induced increases in serum ALP and gamma-GT levels when rats were fed on diet S600.
Authors:
P F Moundipa; F M Domngang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of nutrition     Volume:  65     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  1991 Jan 
Date Detail:
Created Date:  1991-04-03     Completed Date:  1991-04-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  81-91     Citation Subset:  IM    
Affiliation:
Laboratoire de Biochimie, Faculté des Sciences, Yaoundé, Cameroun.
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MeSH Terms
Descriptor/Qualifier:
Aflatoxin B1
Aflatoxins / pharmacokinetics*
Aminopyrine N-Demethylase / analysis
Animals
Diet
Enzyme Activation
Female
Glucuronosyltransferase / analysis
Glutathione Transferase / analysis
Metabolic Detoxication, Drug
Microsomes, Liver / enzymology*
Rats
Rats, Inbred Strains
Vegetables*
Chemical
Reg. No./Substance:
0/Aflatoxins; 1162-65-8/Aflatoxin B1; EC 1.5.3.-/Aminopyrine N-Demethylase; EC 2.4.1.17/Glucuronosyltransferase; EC 2.5.1.18/Glutathione Transferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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