Document Detail

Effect of leaf extract from Clerodendron colebrookianum on blood pressure in rats.
MedLine Citation:
PMID:  7915249     Owner:  NLM     Status:  MEDLINE    
Hypotensive effect of the extract of leaves of C. colebrookianum was investigated. An extremely bitter fraction was isolated, which gave positive test for alkaloids. The fraction produced fall of blood pressure in a dose dependent manner. The fall of blood pressure was blocked by atropine. Hypertensive effects of adrenaline and noradrenaline were slightly antagonised by the alkaloidal extract.
M Gupta; U K Mazumder; S Das
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of experimental biology     Volume:  32     ISSN:  0019-5189     ISO Abbreviation:  Indian J. Exp. Biol.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-09-28     Completed Date:  1994-09-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0233411     Medline TA:  Indian J Exp Biol     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  216-7     Citation Subset:  IM    
Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
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MeSH Terms
Adrenergic alpha-Antagonists / isolation & purification,  pharmacology
Alkaloids / isolation & purification,  pharmacology*,  therapeutic use,  toxicity
Antihypertensive Agents / isolation & purification,  pharmacology*,  therapeutic use,  toxicity
Atropine / pharmacology
Blood Pressure / drug effects*
Drug Interactions
Epinephrine / toxicity
Hypertension / chemically induced,  drug therapy
Hypotension / chemically induced
Norepinephrine / toxicity
Plant Extracts / pharmacology*,  therapeutic use,  toxicity
Plants, Medicinal*
Rats, Wistar
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Alkaloids; 0/Antihypertensive Agents; 0/Plant Extracts; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 51-55-8/Atropine

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