| Effect of leaf extract from Clerodendron colebrookianum on blood pressure in rats. | |
MedLine Citation:
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PMID: 7915249 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypotensive effect of the extract of leaves of C. colebrookianum was investigated. An extremely bitter fraction was isolated, which gave positive test for alkaloids. The fraction produced fall of blood pressure in a dose dependent manner. The fall of blood pressure was blocked by atropine. Hypertensive effects of adrenaline and noradrenaline were slightly antagonised by the alkaloidal extract. |
Authors:
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M Gupta; U K Mazumder; S Das |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Indian journal of experimental biology Volume: 32 ISSN: 0019-5189 ISO Abbreviation: Indian J. Exp. Biol. Publication Date: 1994 Mar |
Date Detail:
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Created Date: 1994-09-28 Completed Date: 1994-09-28 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0233411 Medline TA: Indian J Exp Biol Country: INDIA |
Other Details:
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Languages: eng Pagination: 216-7 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Antagonists
/
isolation & purification,
pharmacology Alkaloids / isolation & purification, pharmacology*, therapeutic use, toxicity Animals Antihypertensive Agents / isolation & purification, pharmacology*, therapeutic use, toxicity Atropine / pharmacology Blood Pressure / drug effects* Drug Interactions Epinephrine / toxicity Hypertension / chemically induced, drug therapy Hypotension / chemically induced India Male Norepinephrine / toxicity Plant Extracts / pharmacology*, therapeutic use, toxicity Plants, Medicinal* Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Antagonists; 0/Alkaloids; 0/Antihypertensive Agents; 0/Plant Extracts; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 51-55-8/Atropine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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