| Effect of lamotrigine combined with felbamate on the horizontal (ambulatory) activity in mice. | |
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MedLine Citation:
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PMID: 16146085 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exploratory and spontaneous locomotor activities, after administration of some novel antiepileptic drugs (felbamate and lamotrigine alone or in combination), were evaluated in mice by means of the electronically monitored locomotor activity system (Digiscan analyzer). Felbamate (injected intraperitoneally, at the single dose of 25.7 mg/kg) significantly reduced behavioral activity in terms of horizontal (ambulatory) activity in mice. The combination of felbamate (25.7 mg/kg) with lamotrigine (2.3 mg/kg) drastically reduced this parameter during the first 15-min period (habituation to a novel environment--being the rate of exploratory locomotor activity) and the second 15-min interval (spontaneous locomotor activity). Moreover, neither the exploratory, nor spontaneous locomotor activity of the mice, were affected by lamotrigine (at the separate dose of 2.3 mg/kg) with respect to the ambulatory activity of the animals tested. Felbamate administered alone or combined with lamotrigine considerably impaired exploratory and spontaneous locomotor activities of the animals tested in terms of horizontal activity. |
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Authors:
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Jarogniew J Luszczki; Marta M Andres; Mariusz J Swiader |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annales Universitatis Mariae Curie-Skłodowska. Sectio D: Medicina Volume: 59 ISSN: 0066-2240 ISO Abbreviation: Ann Univ Mariae Curie Sklodowska Med Publication Date: 2004 |
Date Detail:
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Created Date: 2005-09-08 Completed Date: 2005-09-22 Revised Date: 2009-06-05 |
Medline Journal Info:
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Nlm Unique ID: 0414101 Medline TA: Ann Univ Mariae Curie Sklodowska Med Country: Poland |
Other Details:
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Languages: eng Pagination: 235-40 Citation Subset: IM |
Affiliation:
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Department of Pathophysiology, Skubiszewski Medical University of Lublin. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticonvulsants / toxicity* Behavior, Animal / drug effects* Exploratory Behavior / drug effects Male Mice Motor Activity / drug effects* Phenylcarbamates Propylene Glycols / toxicity* Triazines / toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Phenylcarbamates; 0/Propylene Glycols; 0/Triazines; 25451-15-4/felbamate; 84057-84-1/lamotrigine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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