Document Detail


Effect of lactic acid and iontophoresis on drug permeation across rabbit ear skin.
MedLine Citation:
PMID:  15725558     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this paper was to explore the efficacy of lactic acid as permeation enhancer for drug molecules across the skin. Three model permeants were chosen: acetaminophen (non-ionized), buspirone hydrochloride (cationic drug) and ibuprofen lysine (anionic drug). We also explored the association of lactic acid and iontophoresis as a means of enhancing drug delivery. Permeation experiments were performed in vitro, using rabbit ear skin as barrier. The results obtained indicate that lactic acid has some effects on model drug permeation across the skin. The effect was more evident with the anionic drug ibuprofen. Cathodal intophoresis increased ibuprofen transport, but when lactic acid was associated with cathodal iontophoresis, a concentration-dependent reduction of ibuprofen iontophoretic flux was observed, probably for the competition by the co-ion. The application of electric current (anodal iontophoresis) to a solution of acetaminophen produced an increase in its transport, due to the presence of an electroosmotic contribution; however, the effect of the association of anodal iontophoresis and lactic acid produced no further enhancement.
Authors:
P Sebastiani; S Nicoli; P Santi
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  292     ISSN:  0378-5173     ISO Abbreviation:  Int J Pharm     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-02-23     Completed Date:  2005-12-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  119-26     Citation Subset:  IM    
Affiliation:
Dipartimento Farmaceutico, University of Parma, Parco Area delle Scienze, 43100 Parma, Italy.
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MeSH Terms
Descriptor/Qualifier:
Acetaminophen / administration & dosage,  metabolism,  pharmacokinetics
Administration, Topical
Animals
Biological Availability
Buspirone / administration & dosage,  metabolism,  pharmacokinetics
Cell Membrane Permeability / drug effects*,  physiology
Drug Evaluation, Preclinical / methods
Ear / pathology*
Excipients / chemistry,  pharmacokinetics
Ibuprofen / administration & dosage,  analogs & derivatives,  metabolism,  pharmacokinetics
Iontophoresis / methods*
Lactic Acid / administration & dosage,  metabolism,  pharmacokinetics*
Lysine / administration & dosage,  analogs & derivatives,  metabolism,  pharmacokinetics
Rabbits
Skin Absorption / drug effects*,  physiology
Chemical
Reg. No./Substance:
0/Excipients; 103-90-2/Acetaminophen; 15687-27-1/Ibuprofen; 36505-84-7/Buspirone; 50-21-5/Lactic Acid; 56-87-1/Lysine; 57469-77-9/solufenum

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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