| Effect of labetalol on indices of myocardial necrosis in patients with suspected acute infarction. | |
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MedLine Citation:
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PMID: 3816835 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of combined alpha and beta blockade as a means of limiting infarct size has been studied in a randomised controlled trial using labetalol. Only 166 of 630 (26%) consecutive patients admitted to a cardiac care unit with suspected myocardial infarction were deemed suitable for inclusion; most of the remainder had delayed admission to hospital, were over the age limit of 75, or had complications which precluded the use of labetalol. Those on active treatment received a loading dose followed by a slow intravenous infusion over six hours, and oral therapy for the subsequent five days. Doses were adjusted to maintain systolic pressure in the range 100 to 120 mmHg. The control group received only conventional therapy. Labetalol caused lowering of the blood pressure and heart rate during the phase of intravenous treatment, but little effect occurred subsequently because oral dosage was constrained by low systolic pressures. The group that received active treatment had significantly greater release of CKMB enzyme. Little difference was observed in R wave scores or ejection fraction. Only low doses of labetalol can be used for most patients with acute myocardial infarction. Labetalol cannot be recommended as routine treatment for normotensive patients admitted to hospital with suspected infarction. |
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Authors:
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M E Heber; E Rosenthal; N Thomas; V L Haskett; R D Burwood; J Lutkin; R Vincent; D A Chamberlain |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: European heart journal Volume: 8 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 1987 Jan |
Date Detail:
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Created Date: 1987-04-13 Completed Date: 1987-04-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 11-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Pressure / drug effects Coronary Circulation / drug effects Creatine Kinase / metabolism Female Heart Rate / drug effects Humans Isoenzymes Labetalol / administration & dosage*, pharmacology, therapeutic use Male Middle Aged Myocardial Infarction / drug therapy*, enzymology Stroke Volume / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Isoenzymes; 36894-69-6/Labetalol; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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