Document Detail

Effect of labetalol on exercise tolerance and double product in mild to moderate essential hypertension.
MedLine Citation:
PMID:  4014269     Owner:  NLM     Status:  MEDLINE    
Maximal exercise capacity after control of resting blood pressure with labetalol was studied in nine hypertensive men aged 34 to 69 years (average 52 years). Subjects exercised to exhaustion on an upright cycle ergometer with workload increased as a step function by 25 watts every three minutes, both before and after control of blood pressure was obtained. Mean exercise capacity expressed as total time of exercise until exhaustion was 936 seconds prior to control of the resting blood pressure and 884 seconds (no significant difference) after control of resting blood pressure with labetalol. Double product at peak exercise fell from 254 X 10(2) mm Hg beats per minute prior to blood pressure control to 183 X 10(2) mm Hg beats per minute (p = 0.006) after control of blood pressure with labetalol. The difference in the means of resting heart rate and both peak blood pressure and peak heart rate with exercise were all statistically significant after control of blood pressure with labetalol. These findings suggest that labetalol has an ideal exercise profile affording a cardioprotective effect by decreasing double product but without sacrificing exercise capacity.
A Feit; R Holtzman; M Cohen; N el-Sherif
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of medicine     Volume:  78     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1985 Jun 
Date Detail:
Created Date:  1985-08-02     Completed Date:  1985-08-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  937-41     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure / drug effects
Ethanolamines / pharmacology*
Exercise Test
Heart Rate / drug effects
Hemodynamics / drug effects*
Hypertension / drug therapy*
Labetalol / pharmacology*
Middle Aged
Physical Exertion / drug effects*
Reg. No./Substance:
0/Ethanolamines; 36894-69-6/Labetalol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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