| Effect of itch, scratching and mental stress on autonomic nervous system function in atopic dermatitis. | |
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MedLine Citation:
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PMID: 20574599 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Atopic dermatitis is a stress-responsive disorder that involves the autonomic nervous system. The current study used heart rate variability to examine the effect of itch, scratching and mental stress in atopic patients with moderate to severe disease. Twenty-one patients with active disease and 24 healthy volunteers participated in the study. Heart rate variability measurements were taken at 5 min intervals at rest and after each of 3 acute stress tests, which included histamine-induced itch at the forearm, scratching around the itch site, and the Trier Social Stress Test. Atopic patients displayed a higher heart rate than healthy controls in all 4 experimental settings, which was statistically significant using Cohen's delta analysis. The very low frequency component of the power spectrum, indicative of sympathetic activity, showed a 200% increase after scratching in patients with atopic dermatitis. The high frequency component, reflecting parasympathetic tone, responded swiftly to itch and scratching in healthy controls, but displayed a limited adaptability in atopic dermatitis. This study supports the concept that atopic dermatitis is a stress-responsive disorder and involves autonomic nervous system dysfunction. Atopic subjects exhibited an overactive sympathetic response to itch and scratching, while the parasympathetic tone was persistently and rigidly elevated, showing a lack of adaptability in response to stress. |
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Authors:
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Bryant W Tran; Alexandru D P Papoiu; Carmen V Russoniello; Hui Wang; Tejesh S Patel; Yiong-Huak Chan; Gil Yosipovitch |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta dermato-venereologica Volume: 90 ISSN: 1651-2057 ISO Abbreviation: Acta Derm. Venereol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-24 Completed Date: 2010-10-12 Revised Date: 2012-01-02 |
Medline Journal Info:
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Nlm Unique ID: 0370310 Medline TA: Acta Derm Venereol Country: Sweden |
Other Details:
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Languages: eng Pagination: 354-61 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston-Salem, NC 27157, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Psychological Administration, Cutaneous Adolescent Adult Autonomic Nervous System / physiopathology* Case-Control Studies Dermatitis, Atopic / physiopathology*, psychology Electric Capacitance Female Heart Rate* Histamine / administration & dosage Humans Iontophoresis Male Middle Aged Plethysmography Pruritus / physiopathology*, psychology Severity of Illness Index Stress, Psychological / physiopathology*, psychology Time Factors Water Loss, Insensible Young Adult |
| Chemical | |
Reg. No./Substance:
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51-45-6/Histamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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