| Effect of isosorbide mononitrate for cervical ripening before surgical termination of pregnancy in the first trimester. | |
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MedLine Citation:
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PMID: 20580361 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the efficacy of isosorbide mononitrate (IMN) for cervical ripening prior to first trimester surgical termination of pregnancy. METHODS: A prospective, double-blind, randomized, placebo-controlled trial. Women scheduled for surgical termination of a nonviable fetus before 12 weeks of gestation from October 2008 to June 2009 were enrolled and randomly assigned to receive either 20 mg vaginally of IMN (n=24) or a placebo (n=24) 4 hours before suction evacuation. Cervical dilation before evacuation was assessed with 10-mm Hegar dilators followed by smaller sizes that were measured until the instrument passed freely through the internal os. Cervical dilation, adverse effects, termination complications, and patient satisfaction were the main outcomes. RESULTS: Mean cervical dilation was not significantly different between the IMN and placebo groups (6.29+/-0.99 mm vs 5.71+/-1.04 mm; P=0.05). Mean operative time did not differ between the groups (16+/-0.07 min vs 18+/-0.06 min; P=0.55), nor did patient satisfaction measured by visual analogue scale (7.04+/-1.68 vs 6.54+/-1.22; P=0.24). CONCLUSION: IMN was comparable to placebo in terms of efficacy and patient satisfaction for cervical priming prior to first-trimester termination of pregnancy. |
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Authors:
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Poonam Phusaanantakul; Patama Promsonthi; Boonsri Chanrachakul |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2010-07-02 |
Journal Detail:
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Title: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics Volume: 110 ISSN: 1879-3479 ISO Abbreviation: Int J Gynaecol Obstet Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2010-10-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0210174 Medline TA: Int J Gynaecol Obstet Country: Ireland |
Other Details:
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Languages: eng Pagination: 145-8 Citation Subset: IM |
Copyright Information:
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Copyright 2010. Published by Elsevier Ireland Ltd. |
Affiliation:
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Department of Obstetrics and Gynecology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Induced* Adult Cervical Ripening / drug effects* Double-Blind Method Female Humans Isosorbide Dinitrate / analogs & derivatives*, therapeutic use Labor Stage, First Pregnancy Pregnancy Trimester, First Preoperative Care / methods* Treatment Outcome Vacuum Curettage Vasodilator Agents / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 16051-77-7/isosorbide-5-mononitrate; 87-33-2/Isosorbide Dinitrate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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