Document Detail


Effect of isoproterenol on the metabolism of myocardial fatty acids.
MedLine Citation:
PMID:  3573044     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of beta-adrenergic stimulation on myocardial fatty acid metabolism was studied in the anesthetized open-chest dog. Isoproterenol (1 microgram/kg/min) was infused; and samples of arterial blood and of left ventricular wall were taken at the 5th min for the determination of the following variables: in arterial blood: lactate and serial free fatty acids (FFA); in myocardial tissue: creatine phosphate (CP), ATP, lactate, carnitine, acylcarnitine, glycerol, and the fatty acid content of each of phospholipids (PL), cholesterol esters (CE), triglycerides (TG), diglycerides (DG), monoglycerides (MG), and FFA. A capillary gas chromatography was used for fatty acid assay. Isoproterenol decreased the content of creatine phosphate but not of ATP. Lactate increased in both arterial blood and myocardial tissue. The five-fold increase in arterial FFA (P less than 0.001) was accompanied with a significant increase in FFA serum/tissue ratio. Free carnitine decreased and acylcarnitine increased. Triglycerides content (which is expressed in terms of its total fatty acid content) was considerably reduced by beta-stimulation in comparison with control group (2694 +/- 689 vs. 7518 +/- 833 nmol/g wet wt, P less than 0.001), and tissue glycerol increased (P less than 0.01). The decrease in total MG content was significant, but not that of DG, nor that of CE. Total PL content did not change. The most marked individual changes (except in PL) were observed on monounsaturated fatty acids, 18: 1 omega 9, 18: 1 omega 7, and 16: 1 cis. The significant changes of monounsaturated/saturated and of 16:1 cis/16:1 trans ratios, in arterial FFA and tissue TG, suggested modifications in the distribution of fatty acids.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
S Al Makdessi; J L Andrieu; H Herilier; G Faucon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of molecular and cellular cardiology     Volume:  19     ISSN:  0022-2828     ISO Abbreviation:  J. Mol. Cell. Cardiol.     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-05-27     Completed Date:  1987-05-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0262322     Medline TA:  J Mol Cell Cardiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  141-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / metabolism
Animals
Carnitine / metabolism
Cholesterol Esters / metabolism
Dogs
Fatty Acids / metabolism*
Female
Glycerol / metabolism
Heart Rate / drug effects
Isoproterenol / pharmacology*
Lactates / metabolism
Lipid Mobilization / drug effects
Male
Myocardium / metabolism*
Phosphocreatine / metabolism
Phospholipids / metabolism
Triglycerides / metabolism
Chemical
Reg. No./Substance:
0/Cholesterol Esters; 0/Fatty Acids; 0/Lactates; 0/Phospholipids; 0/Triglycerides; 541-15-1/Carnitine; 56-65-5/Adenosine Triphosphate; 56-81-5/Glycerol; 67-07-2/Phosphocreatine; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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