Document Detail

Effect of isoproterenol on induction of ventricular tachyarrhythmias in the normal and infarcted canine heart.
MedLine Citation:
PMID:  2269535     Owner:  NLM     Status:  MEDLINE    
The influence of isoproterenol on induction of ventricular arrhythmias was evaluated in 10 normal dogs and 17 dogs with experimentally induced myocardial infarction. Programmed stimulation (using up to 6 extrastimuli) was performed before and then during infusion of isoproterenol (2 micrograms/minute followed by 4 micrograms/minute). Isoproterenol facilitated induction of sustained monomorphic ventricular tachycardia (cycle length 163 +/- 26 msec) in 5 of the 10 animals with no inducible baseline arrhythmia (P less than 0.05). Isoproterenol did not affect cycle length or the number of extrastimuli required in animals with baseline ventricular tachycardia (cycle length 158 +/- 15 msec before versus 163 +/- 17 msec during isoproterenol, P = 0.3; extrastimuli 3.8 +/- 0.6 before versus 3.8 +/- 0.4 during isoproterenol infusion, P = 0.3). Isoproterenol did not significantly facilitate induction of ventricular fibrillation in either normal dogs or those studied after production of myocardial infarction. We conclude that infusion of isoproterenol increases the incidence of inducible ventricular tachycardia in the infarcted heart, but does not facilitate the induction of ventricular fibrillation in infarcted or normal hearts, despite the use of an aggressive protocol for programmed stimulation. Isoproterenol is, therefore, a safe and useful adjunct to programmed stimulation in this setting.
G B Hunt; D L Ross
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cardiology     Volume:  29     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1991-02-21     Completed Date:  1991-02-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  155-61     Citation Subset:  IM    
Cardiology Unit, Westmead Hospital, New South Wales, Australia.
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MeSH Terms
Heart Rate / drug effects*
Isoproterenol / pharmacology*,  therapeutic use
Myocardial Infarction / drug therapy*
Tachycardia / chemically induced
Ventricular Fibrillation / chemically induced
Reg. No./Substance:

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