Document Detail

Effect of isoflurane on bronchomotor tone in man.
MedLine Citation:
PMID:  3942666     Owner:  NLM     Status:  MEDLINE    
Twenty patients were anaesthetized with thiopentone, the trachea intubated and the lungs ventilated with 70% nitrous oxide and oxygen. Normocapnia was maintained and, following control measurements of the specific conductance of the lower airways (s.Glaw), either 1.7% isoflurane or 1.3% halothane was added to the inspired gas mixture, 10 patients receiving each drug. s.Glaw was measured repeatedly during the next 30 min. There was a tendency for s.Glaw to increase--indicating a reduction in bronchomotor tone--during the administration of isoflurane, the effect approaching statistical significance. The administration of halothane was associated with a significant increase in s.Glaw. There was a statistically significant increase in the expiratory reserve volume, and a decrease in mean respiratory resistance over the tidal range in both groups. These results indicate that isoflurane does not cause an increase in bronchomotor tone, and may have a tendency to decrease it. This suggests that the previously reported increase of respiratory resistance during isoflurane anaesthesia resulted from a reduction in lung volume, rather than a change in bronchomotor tone.
C P Heneghan; N A Bergman; C Jordan; J R Lehane; D M Catley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  58     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-03-12     Completed Date:  1986-03-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  24-8     Citation Subset:  IM    
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MeSH Terms
Airway Resistance / drug effects
Bronchi / drug effects*
Expiratory Reserve Volume
Halothane / pharmacology
Isoflurane / pharmacology*
Methyl Ethers / pharmacology*
Middle Aged
Muscle Tonus / drug effects
Reg. No./Substance:
0/Methyl Ethers; 151-67-7/Halothane; 26675-46-7/Isoflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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