Document Detail


Effect of iron supplementation and malaria prophylaxis in infants on Plasmodium falciparum genotypes and multiplicity of infection.
MedLine Citation:
PMID:  10450425     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During a randomized placebo-controlled trial of chemoprophylaxis against Plasmodium falciparum malaria and iron supplementation, in infants living under conditions of intense transmission, all samples of P. falciparum obtained from children aged 5 and 8 months were genotyped by polymerase chain reaction-restriction fragment length polymorphism analysis for the msp2 locus. One hundred and six blood samples were analysed for the number of concurrent infections (multiplicity), and the allelic family of each msp2 genotype was determined. Mean multiplicity of infection was, overall, 2.76 infections/child, and it was significantly reduced in infants receiving chemoprophylaxis. This finding might help to explain the rebound effect in morbidity observed after prophylaxis was ended. Iron supplementation did not affect multiplicity of infection. In infants receiving placebo only, or placebo and iron supplementation, a significant positive association was observed between the number of infections and parasite densities (Spearman's p = 0.25, P-0.047). This association was lost in the group receiving chemoprophylaxis alone, or in combination with iron. This study showed a significant association of FC27-like msp2 alleles with prospective risk of clinical malaria in children (relative risk = 1.487, P = 0.013). Such an association was also found for the present risk of clinical malaria in infants receiving prophylaxis (odds ratio = 3.84, P = 0.026), which might imply that chemoprophylaxis may impair the development of premunition.
Authors:
H P Beck; I Felger; P Vounatsou; R Hirt; M Tanner; P Alonso; C Menendez
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Transactions of the Royal Society of Tropical Medicine and Hygiene     Volume:  93 Suppl 1     ISSN:  0035-9203     ISO Abbreviation:  Trans. R. Soc. Trop. Med. Hyg.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-08-31     Completed Date:  1999-08-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7506129     Medline TA:  Trans R Soc Trop Med Hyg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  41-5     Citation Subset:  IM    
Affiliation:
Swiss Tropical Institute, Basel, Switzerland. beckhp@ubaclu.unibas.ch
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MeSH Terms
Descriptor/Qualifier:
Anemia, Iron-Deficiency / prevention & control
Animals
Antigens, Protozoan / genetics
Antigens, Surface / genetics
Antimalarials / therapeutic use*
Cross-Sectional Studies
Genotype
Humans
Infant
Iron / administration & dosage*
Logistic Models
Malaria, Falciparum / parasitology,  prevention & control*
Plasmodium falciparum / drug effects*,  genetics
Protozoan Proteins / genetics
Chemical
Reg. No./Substance:
0/Antigens, Protozoan; 0/Antigens, Surface; 0/Antimalarials; 0/Protozoan Proteins; 0/merozoite surface protein 2, Plasmodium; 7439-89-6/Iron

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