Document Detail

Effect of iron reduction by phlebotomy in Japanese patients with nonalcoholic steatohepatitis: A pilot study.
MedLine Citation:
PMID:  16971174     Owner:  NLM     Status:  In-Data-Review    
Increased hepatic iron deposition may play a role in the pathogenesis of nonalcoholic steatohepatitis (NASH). This study aimed to test whether iron removal by phlebotomy improves serum transaminase activities in patients with NASH. Eleven patients (six males and five females) with biopsy-proven NASH underwent phlebotomy biweekly until they reached near-iron deficiency (NID) (serum ferritin concentration lower than or equal to 30ng/ml). Nine patients completed this study. Serum ferritin levels in these patients fell from 563+/-322 to 18+/-9ng/ml (p=0.001). The treatment reduced mean serum alanine aminotransferase (ALT) activity from 126+/-47 to 56+/-17IU/l (p=0.002). Their weight did not change significantly throughout the study period. Although two patients withdrew from the study, none was affected by any side effects of repeated phlebotomy that required discontinuing the treatment. In conclusion, this pilot study suggests that iron reduction therapy by phlebotomy will be one of the promising therapies for NASH.
Yoshio Sumida; Kazuyuki Kanemasa; Kohei Fukumoto; Naohisa Yoshida; Kyoko Sakai; Toshiaki Nakashima; Takeshi Okanoue
Related Documents :
3374544 - Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or m...
10399124 - A new modification of rotationplasty in a patient with proximal femoral focal deficienc...
12771534 - Vitamin c in chronic kidney disease and hemodialysis patients.
19225914 - High prevalence of restless legs syndrome among patients with polycytemia vera treated ...
9484924 - Phase i/ii trial of batimastat, a matrix metalloproteinase inhibitor, in patients with ...
21641354 - A randomized study of transendocardial injection of autologous bone marrow mononuclear ...
Publication Detail:
Type:  Journal Article     Date:  2006-09-12
Journal Detail:
Title:  Hepatology research : the official journal of the Japan Society of Hepatology     Volume:  36     ISSN:  1386-6346     ISO Abbreviation:  Hepatol. Res.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9711801     Medline TA:  Hepatol Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  315-21     Citation Subset:  -    
Department of Gastroenterology and Hepatology, Nara City Hospital, Higashi-kidera cho 1-50-1, Nara 630-8305, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Measurement of hepatitis B virus core-related antigen as predicting factor for relapse after cessati...
Next Document:  Real-time PCR for mumps diagnosis on clinical specimens--comparison with results of conventional met...