Document Detail

Effect of iron reduction by phlebotomy in Japanese patients with nonalcoholic steatohepatitis: A pilot study.
MedLine Citation:
PMID:  16971174     Owner:  NLM     Status:  In-Data-Review    
Increased hepatic iron deposition may play a role in the pathogenesis of nonalcoholic steatohepatitis (NASH). This study aimed to test whether iron removal by phlebotomy improves serum transaminase activities in patients with NASH. Eleven patients (six males and five females) with biopsy-proven NASH underwent phlebotomy biweekly until they reached near-iron deficiency (NID) (serum ferritin concentration lower than or equal to 30ng/ml). Nine patients completed this study. Serum ferritin levels in these patients fell from 563+/-322 to 18+/-9ng/ml (p=0.001). The treatment reduced mean serum alanine aminotransferase (ALT) activity from 126+/-47 to 56+/-17IU/l (p=0.002). Their weight did not change significantly throughout the study period. Although two patients withdrew from the study, none was affected by any side effects of repeated phlebotomy that required discontinuing the treatment. In conclusion, this pilot study suggests that iron reduction therapy by phlebotomy will be one of the promising therapies for NASH.
Yoshio Sumida; Kazuyuki Kanemasa; Kohei Fukumoto; Naohisa Yoshida; Kyoko Sakai; Toshiaki Nakashima; Takeshi Okanoue
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Publication Detail:
Type:  Journal Article     Date:  2006-09-12
Journal Detail:
Title:  Hepatology research : the official journal of the Japan Society of Hepatology     Volume:  36     ISSN:  1386-6346     ISO Abbreviation:  Hepatol. Res.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9711801     Medline TA:  Hepatol Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  315-21     Citation Subset:  -    
Department of Gastroenterology and Hepatology, Nara City Hospital, Higashi-kidera cho 1-50-1, Nara 630-8305, Japan.
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