Document Detail

Effect of iron-fortified foods on hematologic and biological outcomes: systematic review of randomized controlled trials.
MedLine Citation:
PMID:  22760566     Owner:  NLM     Status:  Publisher    
BACKGROUND: The utility of iron fortification of food to improve iron deficiency, anemia, and biological outcomes is not proven unequivocally. OBJECTIVES: The objectives were to evaluate 1) the effect of iron fortification on hemoglobin and serum ferritin and the prevalence of iron deficiency and anemia, 2) the possible predictors of a positive hemoglobin response, 3) the effect of iron fortification on zinc and iron status, and 4) the effect of iron-fortified foods on mental and motor development, anthropometric measures, and infections. DESIGN: Randomized and pseudorandomized controlled trials that included food fortification or biofortification with iron were included. RESULTS: Data from 60 trials showed that iron fortification of foods resulted in a significant increase in hemoglobin (0.42 g/dL; 95% CI: 0.28, 0.56; P < 0.001) and serum ferritin (1.36 μg/L; 95% CI: 1.23, 1.52; P < 0.001), a reduced risk of anemia (RR: 0.59; 95% CI: 0.48, 0.71; P < 0.001) and iron deficiency (RR: 0.48; 95% CI: 0.38, 0.62; P < 0.001), improvement in other indicators of iron nutriture, and no effect on serum zinc concentrations, infections, physical growth, and mental and motor development. Significant heterogeneity was observed for most of the evaluated outcomes. Sensitivity analyses and meta-regression for hemoglobin suggested a higher response with lower trial quality (suboptimal allocation concealment and blinding), use of condiments, and sodium iron edetate and a lower response when adults were included. CONCLUSION: Consumption of iron-fortified foods results in an improvement in hemoglobin, serum ferritin, and iron nutriture and a reduced risk of remaining anemic and iron deficient.
Tarun Gera; Harshpal Singh Sachdev; Erick Boy
Related Documents :
15315906 - Postnatal intracerebroventricular exposure to leptin causes an altered adult female phe...
20429736 - Child body mass index, obesity, and proximity to fast food restaurants.
17320056 - Central interleukin-1 (il1) signaling is required for pharmacological, but not physiolo...
11863396 - Weight-loss drugs and supplements: are there safer alternatives?
1897396 - Residue trypsin inhibitor: data needs for risk assessment.
18967136 - Determination of rhodium in waters by mg-w cell-electrodeposition and electrothermal at...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-3
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  -     ISSN:  1938-3207     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
S.L. Jain Hospital, Delhi, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effectiveness of preventive school-based obesity interventions in low- and middle-income countries: ...
Next Document:  The lack of effect of insulin on luteinizing hormone pulsatility in healthy male volunteers provides...