| Effect of irbesartan monotherapy compared with ACE inhibitors and calcium-channel blockers on patient compliance in essential hypertension patients: a multicenter, open-labeled, three-armed study. | |
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MedLine Citation:
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PMID: 16029995 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: This multicenter, three-armed, open-labeled study investigated patient compliance of patients receiving irbesartan, angiotensin-converting enzyme (ACE) inhibitors or calcium-channel blockers (CCB) for essential hypertension for a 6-month period. Patients were either newly diagnosed or switched from existing antihypertensive medication due to lack of efficacy or side-effects. METHODS: Patients were started monotherapy with irbesartan (n = 377), ACE inhibitors (n = 298) or CCB (n = 308) and were reevaluated on 1st, 3rd, and 6th months of the treatment. The primary endpoint was patient compliance, assessed by proportion of patients who had taken their study medication every day. Efficacy was recorded as mean reductions in blood pressure and the proportion of patients whose blood pressure normalized. Tolerability was assessed by reported adverse events. RESULTS: Significantly more patients receiving irbesartan had complied with study medication after 3 and 6 months of treatment than ACE inhibitors or CCB. Significantly fewer patients receiving irbesartan needed to change their antihypertensive medication. All three study treatments exhibited similar efficacy profiles, but irbesartan had significantly less adverse events. CONCLUSIONS: This study demonstrated that patient compliance to irbesartan was significantly superior to other study treatments. Irbesartan is therefore a suitable first-line therapy for essential hypertension in everyday clinical practice. |
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Authors:
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Nevres Koylan; Esmeray Acarturk; Aykan Canberk; Nail Caglar; Sali Caglar; Serap Erdine; Sema Guneri; Baris Ilerigelen; Giray Kabakci; Remzi Onder; Olcay Sagkan; Kemalettin Buyukozturk; |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: Blood pressure. Supplement Volume: 14 Suppl 1 ISSN: 0803-8023 ISO Abbreviation: Blood Press Suppl Publication Date: 2005 |
Date Detail:
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Created Date: 2005-07-20 Completed Date: 2009-01-28 Revised Date: 2010-05-18 |
Medline Journal Info:
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Nlm Unique ID: 9300787 Medline TA: Blood Press Suppl Country: Norway |
Other Details:
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Languages: eng Pagination: 23-31 Citation Subset: IM |
Affiliation:
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Istanbul University Istanbul Faculty of Medicine, Istanbul, Turkey. nevres@koylan.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Angiotensin-Converting Enzyme Inhibitors / therapeutic use* Antihypertensive Agents / adverse effects, therapeutic use* Biphenyl Compounds / adverse effects, therapeutic use* Blood Pressure / drug effects Calcium Channel Blockers / therapeutic use* Constipation / chemically induced Female Headache / chemically induced Heartburn / chemically induced Humans Hypertension / diagnosis, drug therapy* Male Middle Aged Multivariate Analysis Nausea / chemically induced Patient Compliance* Tetrazoles / adverse effects, therapeutic use* Time Factors Treatment Outcome Xerostomia / chemically induced |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Biphenyl Compounds; 0/Calcium Channel Blockers; 0/Tetrazoles; 138402-11-6/irbesartan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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