| Effect of ionizing radiation on chemical and biological properties of Salmonella minnesota R595 lipopolysaccharide. | |
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MedLine Citation:
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PMID: 7185268 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lipopolysaccharide of the Salmonella minnesota Re mutant R595 was irradiated with 60Co gamma doses of 50, 100, 150 and 200 kGy. The irradiated preparations were less toxic, less active in the Shwartzman reaction and as activators of the complement system, but they had retained the protection activity against the lethal action of endotoxin. The irradiation resulted in a dose-dependent decrease in the amounts of constituents (glucosamine, KDO, fatty acids) of the original lipopolysaccharide. With increasing irradiation doses increasing amounts of the irradiated material became dialysable (up to 21% in the 200 kGy sample). Only 50% of total fatty acids were present in the 200 kGy preparation compared to the parent lipopolysaccharide. The degradation products formed during irradiation have not been identified. |
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Authors:
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M El Sabbagh; C Galanos; L Bertók; G Füst; O Lüderitz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta microbiologica Academiae Scientiarum Hungaricae Volume: 29 ISSN: 0001-6187 ISO Abbreviation: Acta Microbiol Acad Sci Hung Publication Date: 1982 |
Date Detail:
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Created Date: 1983-09-23 Completed Date: 1983-09-23 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370333 Medline TA: Acta Microbiol Acad Sci Hung Country: HUNGARY |
Other Details:
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Languages: eng Pagination: 255-61 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Complement Activation Drug Tolerance Female Gamma Rays Glucosamine / analysis Hemorrhage Lethal Dose 50 Male Polysaccharides, Bacterial / radiation effects* Rabbits Rats Salmonella / metabolism* Sugar Acids / analysis |
| Chemical | |
Reg. No./Substance:
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0/Polysaccharides, Bacterial; 0/Sugar Acids; 1069-03-0/2-keto-3-deoxyoctonate; 3416-24-8/Glucosamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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