Document Detail

Effect of iodoacetic acid upon cochlear potentials.
MedLine Citation:
PMID:  3478950     Owner:  NLM     Status:  MEDLINE    
Lotz et al. reported that perilymphatic application of 5 X 10(-3) M iodoacetic acid (IAA) in the guinea pig does not influence the first-order cochlear microphonics (CM1) under aerobic conditions. However, in ischemia the rate of decline of the second-order microphonics (CM II, also called postmortem CM) was significantly increased by IAA. The authors concluded that glycolysis plays no role in maintaining the CMI, but that it is responsible for supporting the CMII. In carefully controlled experiments we found that in the respiring guinea pig, perilymphatic application of 5 X 10(-3) M IAA produced a rapid and pronounced effect upon both the endolymphatic potential and the CM. In particular, the CM dropped to less than 0.5% of its initial level within 40 min, due to IAA, whereas it took 120 min to drop to the same level in total ischemia (without IAA). We therefore reject the above-mentioned proposition that IAA is ineffective upon cochlear potentials under aerobic conditions; moreover, we find that even under aerobic conditions, the CM drops well below the usual CM II level substantially faster than under anaerobic conditions (without IAA). Other important findings, including an anoxia-sensitive negative component of the endolymphatic potential due to severe intoxication with IAA, and the effects of pretreatment of the organ of Corti with low concentrations of IAA upon the CM II are discussed.
T Kobayashi; I Ise; D C Marcus; R Thalmann
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Acta oto-laryngologica. Supplementum     Volume:  435     ISSN:  0365-5237     ISO Abbreviation:  Acta Otolaryngol Suppl     Publication Date:  1987  
Date Detail:
Created Date:  1987-12-17     Completed Date:  1987-12-17     Revised Date:  2008-02-13    
Medline Journal Info:
Nlm Unique ID:  0370355     Medline TA:  Acta Otolaryngol Suppl     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  46-54     Citation Subset:  IM    
Department of Otolaryngology, Tohoku University School of Medicine, Sendai, Japan.
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MeSH Terms
Aerobiosis / drug effects
Cerebellum / blood supply
Cochlear Microphonic Potentials / drug effects*
Evoked Potentials, Auditory / drug effects*
Guinea Pigs
Infusions, Intra-Arterial
Iodoacetates / pharmacology*
Iodoacetic Acid
Grant Support
Reg. No./Substance:
0/Iodoacetates; 64-69-7/Iodoacetic Acid

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