Document Detail


Effect of iodixanol and ioxilan on QT interval and renal function in patients with systolic heart failure.
MedLine Citation:
PMID:  20870304     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: Contrast media (CM) exposure is associated with a substantial risk of arrhythmias and nephrotoxicity. These adverse effects may be exacerbated in high-risk conditions such as heart failure, although no studies have evaluated newer CM agents in this population. This study evaluated the electrophysiologic and renal effects of two newer CM agents, iodixanol and ioxilan, in heart failure patients undergoing angiography.
METHODS: Eighty-seven consecutive systolic heart failure patients who received either iso-osmolar iodixanol (n=44) or low-osmolar ioxilan (n=43), stratified for concomitant amiodarone, were evaluated for QT interval and serum creatinine changes in comparison to baseline. QT values were corrected according to three formulae: Bazett's correction, Fridericia formula, and Framingham equation.
RESULTS: Baseline patient characteristics were not significantly different in the iodixanol versus ioxilan groups, except for myocardial infarction and renal disease. No significant change in mean QTc was observed after exposure to either CM agent compared to baseline. These results were unaffected by amiodarone. A significant improvement in serum creatinine from baseline was observed in the iodixanol group compared to the ioxilan group (-0.121±0.35mg/dL vs. 0.033±0.23mg/dL, respectively; p=0.045).
CONCLUSIONS: No significant change in QTc interval was observed in patients receiving either iodixanol or ioxilan during angiography. Iodixanol appeared to improve short-term renal function in patients with heart failure and should be further investigated.
Authors:
Sheryl L Chow; Tien M H Ng; Roman A Litwinski; Simon Kangavari; Mason Weiss
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Publication Detail:
Type:  Journal Article     Date:  2010-09-25
Journal Detail:
Title:  International journal of cardiology     Volume:  154     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  17-21     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Western University of Health Sciences, College of Pharmacy, Pomona, CA, United States; Centinela-Freeman Regional Medical Center, Inglewood, CA, United States; LABioMed at Harbor-UCLA, Torrance, CA, United States.
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