Document Detail

Effect of intraventricular administration of calcium and calmodulin antagonist on the blood pressure in the rat.
MedLine Citation:
PMID:  2962018     Owner:  NLM     Status:  MEDLINE    
The effect of intraventricular administration of calcium on the mean arterial pressure in the conscious rat was investigated. Biphasic changes of blood pressure, fugitive rapid increment during the first 3 min and gradual lengthy decrement during the next 60 min were observed by the administration of CaCl2 (30 mumol/kg). Both these changes were significant as compared with the control level. On the other hand, the biphasic response of blood pressure by CaCl2 was abolished by the administration of calmodulin antagonist, W-7, or catecholamine synthesizing enzyme inhibitor, alpha-methyltyrosine. These results are discussed on the basis of our calcium-calmodulin-dependent biogenic amine-synthesizing mechanism.
D Sutoo; T Matsukura; K Akiyama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  82     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-01-28     Completed Date:  1988-01-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  297-302     Citation Subset:  IM    
Institute of Medical Science, University of Tsukuba, Ibaraki-Ken, Japan.
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MeSH Terms
Blood Pressure / drug effects*
Calcium Chloride / administration & dosage,  pharmacology*
Calmodulin / antagonists & inhibitors*
Dopamine / administration & dosage,  pharmacology
Fenclonine / administration & dosage,  pharmacology
Injections, Intraperitoneal
Injections, Intraventricular
Methyltyrosines / administration & dosage,  pharmacology
Rats, Inbred Strains
Sulfonamides / administration & dosage,  pharmacology*
Reg. No./Substance:
0/Calmodulin; 0/Methyltyrosines; 0/Sulfonamides; 10043-52-4/Calcium Chloride; 65595-90-6/W 7; 7424-00-2/Fenclonine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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