| Effect of intraventricular administration of calcium and calmodulin antagonist on the blood pressure in the rat. | |
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MedLine Citation:
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PMID: 2962018 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of intraventricular administration of calcium on the mean arterial pressure in the conscious rat was investigated. Biphasic changes of blood pressure, fugitive rapid increment during the first 3 min and gradual lengthy decrement during the next 60 min were observed by the administration of CaCl2 (30 mumol/kg). Both these changes were significant as compared with the control level. On the other hand, the biphasic response of blood pressure by CaCl2 was abolished by the administration of calmodulin antagonist, W-7, or catecholamine synthesizing enzyme inhibitor, alpha-methyltyrosine. These results are discussed on the basis of our calcium-calmodulin-dependent biogenic amine-synthesizing mechanism. |
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Authors:
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D Sutoo; T Matsukura; K Akiyama |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neuroscience letters Volume: 82 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1987 Dec |
Date Detail:
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Created Date: 1988-01-28 Completed Date: 1988-01-28 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 297-302 Citation Subset: IM |
Affiliation:
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Institute of Medical Science, University of Tsukuba, Ibaraki-Ken, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects* Calcium Chloride / administration & dosage, pharmacology* Calmodulin / antagonists & inhibitors* Dopamine / administration & dosage, pharmacology Fenclonine / administration & dosage, pharmacology Injections, Intraperitoneal Injections, Intraventricular Male Methyltyrosines / administration & dosage, pharmacology Rats Rats, Inbred Strains Sulfonamides / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Calmodulin; 0/Methyltyrosines; 0/Sulfonamides; 10043-52-4/Calcium Chloride; 65595-90-6/W 7; 7424-00-2/Fenclonine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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