| Effect of intravenous tranexamic acid administration on blood loss during and after cesarean delivery. | |
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MedLine Citation:
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PMID: 21872857 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the effect of intravenous tranexamic acid on blood loss during and after cesarean delivery. METHODS: One hundred pregnant women were randomized to receive either 10mg/kg of tranexamic acid or placebo intravenously 20minutes before incision in a double-blind controlled study. Postplacental delivery blood loss, postoperative hemorrhage 2hours after surgery, and oxytocin administration were recorded. RESULTS: The patients' mean age, weight, and duration of surgery were similar between the 2 groups. Mean blood loss was significantly less in the tranexamic acid group compared with the control group for both intraoperative bleeding (262.5±39.6 vs 404.7±94.4mL) and postoperative bleeding (67.1±6.5 vs 141.0±33.9mL; P<0.001), respectively. Oxytocin administration was significantly less in the tranexamic acid group compared with the control group (39±5.8 vs 43±5.4 units; P=0.001). CONCLUSION: Intravenous tranexamic acid decreased intra- and postoperative blood loss and oxytocin administered in patients delivered by cesarean. |
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Authors:
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Ali Movafegh; Laleh Eslamian; Azita Dorabadi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-26 |
Journal Detail:
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Title: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics Volume: - ISSN: 1879-3479 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0210174 Medline TA: Int J Gynaecol Obstet Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Anesthesia and Analgesia Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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