Document Detail

Effect of intravenous tranexamic acid administration on blood loss during and after cesarean delivery.
MedLine Citation:
PMID:  21872857     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To assess the effect of intravenous tranexamic acid on blood loss during and after cesarean delivery. METHODS: One hundred pregnant women were randomized to receive either 10mg/kg of tranexamic acid or placebo intravenously 20minutes before incision in a double-blind controlled study. Postplacental delivery blood loss, postoperative hemorrhage 2hours after surgery, and oxytocin administration were recorded. RESULTS: The patients' mean age, weight, and duration of surgery were similar between the 2 groups. Mean blood loss was significantly less in the tranexamic acid group compared with the control group for both intraoperative bleeding (262.5±39.6 vs 404.7±94.4mL) and postoperative bleeding (67.1±6.5 vs 141.0±33.9mL; P<0.001), respectively. Oxytocin administration was significantly less in the tranexamic acid group compared with the control group (39±5.8 vs 43±5.4 units; P=0.001). CONCLUSION: Intravenous tranexamic acid decreased intra- and postoperative blood loss and oxytocin administered in patients delivered by cesarean.
Ali Movafegh; Laleh Eslamian; Azita Dorabadi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-26
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  -     ISSN:  1879-3479     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
Anesthesia and Analgesia Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
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