Document Detail

Effect of intravenous or intragastric nutrients on food intake in rats.
MedLine Citation:
PMID:  1908926     Owner:  NLM     Status:  MEDLINE    
A series of experiments were performed to determine which components of total parenteral nutrition (TPN) reduce spontaneous food intake (SFI) and to what degree. In Experiment 1, rats were infused with TPN (15% dextrose + 5% fat + 4.3% amino acid) or with one of its three components given independently at the final concentration of TPN for 3 days via an intravenous (iv) catheter. Each solution, at 3 ml/hr, provided a different amount of calories (TPN = 85, dextrose = 37, fat = 36, and amino acid = 12 kcal/day), representing about 120, 50, 50, and 20% of the rat's spontaneous caloric intake, respectively. TPN, dextrose, and fat significantly reduced SFI compared to the infusion of normal saline; however, amino acid failed to reduce SFI. Experiment 2 was carried out to investigate the relative contributions that pre- and postabsorptive mechanisms make in the regulation of SFI. Each rat in four different groups was infused with one of four isocaloric nutrient solutions through an iv catheter and a gastrostomy (ig) for separated periods of time. Nutrient solutions at 3 ml/hr provided each 32 kcal/day (50% of requirements): 13% dextrose, 4.5% fat, 11.4% amino acid, and a mixture (6.4% dextrose + 1.6% fat + 1.7% amino acid). Each solution, either iv or ig, reduced SFI compared to normal saline infused via the same route. However, neither the route of administration nor the nature of different nutrients caused significant differences in SFI reduction.
M Giner; M M Meguid
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of surgical research     Volume:  51     ISSN:  0022-4804     ISO Abbreviation:  J. Surg. Res.     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1991-10-03     Completed Date:  1991-10-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0376340     Medline TA:  J Surg Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  259-66     Citation Subset:  IM    
Department of Surgery, University Hospital, SUNY Health Science Center, Syracuse 13210.
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MeSH Terms
Animal Nutritional Physiological Phenomena*
Energy Intake
Infusions, Intravenous
Intubation, Gastrointestinal
Parenteral Nutrition, Total / methods*
Rats, Inbred F344
Grant Support

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