Document Detail


Effect of intravenous injection of CDP-choline, S-adenosyl-methionine and citiolone in subjects with hyperlipemia.
MedLine Citation:
PMID:  231953     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of some drugs (CDP-choline, S-adenosyl-methionine and acetyl-homocysteinethiolactone) stimulating a number of liver enzymatic activities was studied in hyperlipemic patients to explore the role of liver function in hyperlipidemia. Recently a close connection between liver impairment and hyperlipemia has been observed. Twenty-eight, 13 and 10 hyperlipemic subjects received i.v. doses respectively, of CDP-choline (300 mg), S-adenosyl-methionine (SAMe) (45 mg) and citiolone (300 mg) in 100 ml saline solution during a 30 minute period. Plasma lipid fractions were evaluated basally and at the end of the injection. CDP-choline caused a significant decrease in plasma total lipids (p less than 0.001), cholesterol (p less than 0.01) and triglycerides (p less than 0.01) as well as a slight increase in beta - LP (p less than 0.05). SAMe injection was followed by a significant fall in plasma total lipids (p less than 0.05), cholesterol (p less than 0.001) and beta - LP+pre-beta LP/alpha - LP ratio (p less than 0.05), while alpha -LP increased significantly (p less than 0.05). Citiolone caused only a decrease in plasma cholesterol values (p less than 0.001). The data suggest that the hypolipidemic effect of the three compounds is due to a common mode of action, i.e., the stimulation of hepatic phospholipid biosynthesis, though in a different way.
Authors:
F Galeone; F Salvadorini; M Guarguaglini; P Saba
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Artery     Volume:  5     ISSN:  0098-6127     ISO Abbreviation:  Artery     Publication Date:  1979 Feb 
Date Detail:
Created Date:  1980-05-14     Completed Date:  1980-05-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7508494     Medline TA:  Artery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  157-69     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Cholesterol / blood
Choline / analogs & derivatives*
Cytidine Diphosphate Choline / administration & dosage,  therapeutic use*
Female
Humans
Hyperlipidemias / blood*,  drug therapy
Injections, Intravenous
Lipids / blood*
Lipoproteins, HDL / blood
Lipoproteins, LDL / blood
Male
Middle Aged
S-Adenosylmethionine / administration & dosage,  therapeutic use*
Thiophenes / administration & dosage,  therapeutic use*
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Lipids; 0/Lipoproteins, HDL; 0/Lipoproteins, LDL; 0/Thiophenes; 0/Triglycerides; 29908-03-0/S-Adenosylmethionine; 57-88-5/Cholesterol; 62-49-7/Choline; 987-78-0/Cytidine Diphosphate Choline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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