Document Detail

Effect of intravenous infusion of isotonic sodium bicarbonate solution on acidemic calves with diarrhea.
MedLine Citation:
PMID:  12520117     Owner:  NLM     Status:  MEDLINE    
The effect of 1.35% isotonic sodium bicarbonate solution (ISB) administered intravenously on acid-base equilibrium was examined in 18 acidemic Japanese black beef calves with spontaneous diarrhea. The infusion volumes of ISB were decided based on the first half volumes of base needed. In 72.2% (13/18) of calves, improvement of acidemia was detected. There was good correlation (r=0.693, p<0.01) between infused volume of ISB and changes in base excess (y=1.097x + 4.762). Infusion volumes of ISB were 7.5, 10.2, 12.9 and 15.7 ml/kg, respectively, enough to correcting the first half of 5, 10, 15 and 20 mEq/l of base deficit in acidemic calves. Our finding suggested that ISB could be used to correct metabolic acidosis without altering electrolyte concentrations in calves.
Kazuyuki Suzuki; Tosihide Kato; Gensei Tsunoda; Shigehiro Iwabuchi; Kimi Asano; Ryuji Asano
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The Journal of veterinary medical science / the Japanese Society of Veterinary Science     Volume:  64     ISSN:  0916-7250     ISO Abbreviation:  J. Vet. Med. Sci.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-01-09     Completed Date:  2003-06-09     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9105360     Medline TA:  J Vet Med Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1173-5     Citation Subset:  IM    
Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan.
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MeSH Terms
Acid-Base Equilibrium / drug effects
Acidosis / complications,  drug therapy*,  veterinary*
Cattle Diseases / drug therapy*
Dose-Response Relationship, Drug
Infusions, Intravenous
Isotonic Solutions / administration & dosage,  pharmacology,  therapeutic use
Sodium Bicarbonate / administration & dosage*,  pharmacology,  therapeutic use*
Reg. No./Substance:
0/Isotonic Solutions; 144-55-8/Sodium Bicarbonate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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