| Effect of intravenous immunoglobulin on prednisone dose in patients with pemphigus vulgaris. | |
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MedLine Citation:
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PMID: 17234105 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Current therapeutic options for the treatment of pemphigus vulgaris (PV) are prednisone and immunosuppressants. Patients unresponsive to high-dose systemic corticosteroids and conventional immunosuppressants may respond to intravenous immunoglobulin (IVIG). OBJECTIVE: The primary outcome was the change in prednisone dose at 6 months and 1 year post-IVIG administration. METHODS: A retrospective chart review of PV patients treated at Sunnybrook and Women's College Health Sciences Centre between January 1999 and October 2004 was conducted. Demographic information, corticosteroid and IVIG use, dosage, and the timing of administration for all patients were obtained. RESULTS: Eight PV patients, mean age of 50 years (+/- 14.7 years), were reviewed. There was a significant decrease in mean prednisone dose at 6 months (45%) and 12 months (71%) compared with the mean dose at the start of treatment (p < .05). LIMITATIONS: Concomitant medication use may influence results. CONCLUSION: This study demonstrates that IVIG can lower prednisone doses in PV patients. |
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Authors:
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Nicole Mittmann; Brian Chan; Sandra Knowles; P Régine Mydlarski; Lidia Cosentino; Neil Shear |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cutaneous medicine and surgery Volume: 10 ISSN: 1203-4754 ISO Abbreviation: J Cutan Med Surg Publication Date: 2006 Sep-Oct |
Date Detail:
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Created Date: 2007-01-19 Completed Date: 2007-04-03 Revised Date: 2007-07-04 |
Medline Journal Info:
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Nlm Unique ID: 9614685 Medline TA: J Cutan Med Surg Country: United States |
Other Details:
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Languages: eng Pagination: 222-7 Citation Subset: IM |
Affiliation:
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Division of Clinical Pharmacology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Canada. nicole.mittmann@sunnybrook.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Drug Therapy, Combination Female Glucocorticoids / administration & dosage* Humans Immunoglobulins, Intravenous / administration & dosage* Male Middle Aged Pemphigus / drug therapy* Prednisone / administration & dosage* Retrospective Studies Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 0/Immunoglobulins, Intravenous; 53-03-2/Prednisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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