Document Detail


Effect of intravenous immunoglobulin on prednisone dose in patients with pemphigus vulgaris.
MedLine Citation:
PMID:  17234105     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Current therapeutic options for the treatment of pemphigus vulgaris (PV) are prednisone and immunosuppressants. Patients unresponsive to high-dose systemic corticosteroids and conventional immunosuppressants may respond to intravenous immunoglobulin (IVIG). OBJECTIVE: The primary outcome was the change in prednisone dose at 6 months and 1 year post-IVIG administration. METHODS: A retrospective chart review of PV patients treated at Sunnybrook and Women's College Health Sciences Centre between January 1999 and October 2004 was conducted. Demographic information, corticosteroid and IVIG use, dosage, and the timing of administration for all patients were obtained. RESULTS: Eight PV patients, mean age of 50 years (+/- 14.7 years), were reviewed. There was a significant decrease in mean prednisone dose at 6 months (45%) and 12 months (71%) compared with the mean dose at the start of treatment (p < .05). LIMITATIONS: Concomitant medication use may influence results. CONCLUSION: This study demonstrates that IVIG can lower prednisone doses in PV patients.
Authors:
Nicole Mittmann; Brian Chan; Sandra Knowles; P Régine Mydlarski; Lidia Cosentino; Neil Shear
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cutaneous medicine and surgery     Volume:  10     ISSN:  1203-4754     ISO Abbreviation:  J Cutan Med Surg     Publication Date:    2006 Sep-Oct
Date Detail:
Created Date:  2007-01-19     Completed Date:  2007-04-03     Revised Date:  2007-07-04    
Medline Journal Info:
Nlm Unique ID:  9614685     Medline TA:  J Cutan Med Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  222-7     Citation Subset:  IM    
Affiliation:
Division of Clinical Pharmacology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Canada. nicole.mittmann@sunnybrook.ca
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MeSH Terms
Descriptor/Qualifier:
Drug Therapy, Combination
Female
Glucocorticoids / administration & dosage*
Humans
Immunoglobulins, Intravenous / administration & dosage*
Male
Middle Aged
Pemphigus / drug therapy*
Prednisone / administration & dosage*
Retrospective Studies
Treatment Outcome
Chemical
Reg. No./Substance:
0/Glucocorticoids; 0/Immunoglobulins, Intravenous; 53-03-2/Prednisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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