| Effect of intravenous hydralazine infusion on maternal plasma nitric oxide levels in gestations complicated with severe preeclampsia: a pilot study. | |
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MedLine Citation:
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PMID: 22258304 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AIM: To investigate the effect of intravenous hydralazine infusion on maternal nitric oxide (NO) levels. METHODS: This pilot study comprised 40 (n = 40) gestations complicated with severe preeclampsia to whom maternal plasma NO levels were determined by chemiluminescence before and after hydralazine administration. Blood pressure values were concomitantly assessed. RESULTS: After 20 min of intravenous hydralazine infusion blood pressure values decrease significantly in term and preterm gestations. This was accompanied by an overall significant decrease in mean plasma NO values (38.7 ± 12.9 to 35.4 ± 13.9 μmol/L, p < 0.05). Despite this, NO values decreased in 67.5% of cases (a 17.6% from baseline) and increased in 32.5% (a 14.8% from baseline) (p < 0.05 for both). Blood pressure decrease (%) was lower (systolic and diastolic) among those displaying a NO decrement than in the increment group. Interestingly, gestational age was higher in the group displaying decreased NO; however, this did not reach statistical significance (37.5 ± 2.7 vs. 35.9 ± 2.8 weeks, p = 0.08). CONCLUSION: The results of this study fail to demonstrate a similar NO secretion after hydralazine infusion in women with severe preeclampsia. |
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Authors:
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Enrique Teran; Fernando Briones; Verónica Nicolalde; Sandra Vivero; Peter Chedraui; Faustino R Pérez-López |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-19 |
Journal Detail:
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Title: Archives of gynecology and obstetrics Volume: - ISSN: 1432-0711 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710213 Medline TA: Arch Gynecol Obstet Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Biomedical Center, Universidad Central del Ecuador, Quito, Ecuador, e_teran_uce@hotmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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