Document Detail


Effect of intravenous dopamine on blood pressure and plasma insulin in hypertensive patients.
MedLine Citation:
PMID:  8157035     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eleven patients with moderate to severe hypertension were pre-treated with oral labetalol 800-1200 mg/day for one week, prior to receiving two i.v. infusions of dopamine 1-3 micrograms/kg/min each of 30 min each, before and after the i.v. bolus injection of metoclopramide 30 mg. There were washout periods before and after the metoclopramide administration. Dopamine induced a significant decrease of blood pressure from 172/104 to 153/94 mm Hg without altering heart rate, and it increased the plasma insulin level from 8.3 to 12.1 microU.ml-1. Metoclopramide did not itself affect blood pressure or plasma insulin, but it did block the hypotensive response and rise in plasma insulin due to dopamine. We conclude that the pharmacological actions of intravenous dopamine on the cardiovascular system and on insulin secretion may be mediated by dopaminergic receptor stimulation.
Authors:
G Martin; P Forte; A Luchsinger; F Mendoza; A Urbina-Quintana; O Hernandez Pieretti; E Romero; M Velasco
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  45     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1993  
Date Detail:
Created Date:  1994-05-19     Completed Date:  1994-05-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  503-5     Citation Subset:  IM    
Affiliation:
Clinical Pharmacology Unit, Vargas Medical School, Caracas, Venezuela.
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MeSH Terms
Descriptor/Qualifier:
Blood Glucose / metabolism
Blood Pressure / drug effects*
Dopamine / administration & dosage,  pharmacology*
Female
Heart Rate / drug effects
Humans
Hypertension / blood,  drug therapy,  physiopathology*
Infusions, Intravenous
Insulin / blood*
Labetalol / therapeutic use
Male
Metoclopramide / pharmacology
Middle Aged
Chemical
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin; 364-62-5/Metoclopramide; 36894-69-6/Labetalol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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