| Effect of intravenous cimetidine on mucociliary transport in anesthetized dogs. | |
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MedLine Citation:
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PMID: 6126388 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous studies have shown that aerosolized histamine increases tracheal mucociliary transport velocity, whereas topically administered H1-antihistamines depress mucociliary function. Using a radiolabelled tracer method in anesthetized dogs, we determined tracheal transport velocity (TTV) before and 30 and 60 min after intravenous administration of 150 mg of cimetidine, an H2-antihistamine. In 12 experiments, 30 and 60 min after cimetidine, mean TTV increased significantly (mean changes 5.1 +/- 1.8 and 5.7 +/- 2.6 mm/min, respectively, P less than or equal to 0.05), whereas in seven control experiments in which cimetidine was not given, mean TTV did not change over 1 h (mean change 1.1 +/- 2.5 mm/min; P greater than 0.05). However, the increase in TTV after cimetidine was not significantly different from the spontaneous change in the control animals (P greater than 0.1). These results suggest that cimetidine, unlike H1-antihistamines, does not depress and may possibly improve mucociliary transport function. |
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Authors:
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S A Carson; S K Chopra; D P Tashkin |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: European journal of respiratory diseases Volume: 63 ISSN: 0106-4339 ISO Abbreviation: Eur J Respir Dis Publication Date: 1982 Jul |
Date Detail:
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Created Date: 1982-12-02 Completed Date: 1982-12-02 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8006891 Medline TA: Eur J Respir Dis Country: DENMARK |
Other Details:
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Languages: eng Pagination: 310-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aerosols Anesthesia, Intravenous Animals Cilia / drug effects*, physiology Cimetidine / administration & dosage, pharmacology* Depression, Chemical Dogs Guanidines / pharmacology* Histamine H2 Antagonists / pharmacology Injections, Intravenous Mucus / drug effects*, physiology Receptors, Histamine H2 / drug effects Trachea / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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HL07014/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Aerosols; 0/Guanidines; 0/Histamine H2 Antagonists; 0/Receptors, Histamine H2; 51481-61-9/Cimetidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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