Document Detail


Effect of intravenous cimetidine on mucociliary transport in anesthetized dogs.
MedLine Citation:
PMID:  6126388     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous studies have shown that aerosolized histamine increases tracheal mucociliary transport velocity, whereas topically administered H1-antihistamines depress mucociliary function. Using a radiolabelled tracer method in anesthetized dogs, we determined tracheal transport velocity (TTV) before and 30 and 60 min after intravenous administration of 150 mg of cimetidine, an H2-antihistamine. In 12 experiments, 30 and 60 min after cimetidine, mean TTV increased significantly (mean changes 5.1 +/- 1.8 and 5.7 +/- 2.6 mm/min, respectively, P less than or equal to 0.05), whereas in seven control experiments in which cimetidine was not given, mean TTV did not change over 1 h (mean change 1.1 +/- 2.5 mm/min; P greater than 0.05). However, the increase in TTV after cimetidine was not significantly different from the spontaneous change in the control animals (P greater than 0.1). These results suggest that cimetidine, unlike H1-antihistamines, does not depress and may possibly improve mucociliary transport function.
Authors:
S A Carson; S K Chopra; D P Tashkin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  European journal of respiratory diseases     Volume:  63     ISSN:  0106-4339     ISO Abbreviation:  Eur J Respir Dis     Publication Date:  1982 Jul 
Date Detail:
Created Date:  1982-12-02     Completed Date:  1982-12-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8006891     Medline TA:  Eur J Respir Dis     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  310-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aerosols
Anesthesia, Intravenous
Animals
Cilia / drug effects*,  physiology
Cimetidine / administration & dosage,  pharmacology*
Depression, Chemical
Dogs
Guanidines / pharmacology*
Histamine H2 Antagonists / pharmacology
Injections, Intravenous
Mucus / drug effects*,  physiology
Receptors, Histamine H2 / drug effects
Trachea / drug effects
Grant Support
ID/Acronym/Agency:
HL07014/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Aerosols; 0/Guanidines; 0/Histamine H2 Antagonists; 0/Receptors, Histamine H2; 51481-61-9/Cimetidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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