Document Detail

Effect of intravenous and aerosol administration of 5-hydroxytryptamine on pulmonary function values in healthy calves.
MedLine Citation:
PMID:  1595956     Owner:  NLM     Status:  MEDLINE    
Effects of IV and aerosol administration of 5-hydroxytryptamine (5-HT) on ventilation, pulmonary mechanics values, pulmonary arterial pressure, and heart rate were investigated in healthy unsedated Friesian calves. Minute volume increased significantly, mainly because of an increase in respiratory rate. Except for total pulmonary resistance after bolus injection, continuous administration of 5-HT given by either route caused significant alterations of lung dynamic compliance and total pulmonary resistance, the former decreasing to one-fifth of its baseline value and the latter increasing twofold. Pulmonary arterial pressure increased significantly, whatever the speed or route of administration. Administration of a bolus did not affect heart rate, whereas continuous IV administration of 5-HT as well by perfusion or by aerosol resulted in sustained tachycardia. It was concluded that 5-HT induces reversible bronchoconstriction and pulmonary vasoconstriction in healthy unsedated calves, 5-HT-induced functional alterations depend on the speed of administration, and excess of 5-HT production or depression in uptake by the lungs during bovine respiratory tract diseases could contribute to pulmonary dysfunction.
D J Desmecht; A S Linden; F A Rollin; H Amory; P M Lekeux
Related Documents :
8820786 - Inhaled nitric oxide: effects on hemodynamics, myocardial contractility, and regional b...
7471826 - Effect of chronic pressure overload on the maximal rate of pressure fall of the right v...
1568996 - Bedside evaluation of the resistance of large and medium pulmonary veins in various lun...
9583446 - Plasma thromboxane b2 concentration in patients with ventricular septal defect and pulm...
17879046 - Multistage approach for tracheobronchomalacia caused by a chest deformity in the settin...
576746 - Classification and management of mycotic aneurysms.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of veterinary research     Volume:  53     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-06-30     Completed Date:  1992-06-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  315-20     Citation Subset:  IM    
Laboratory for Functional Investigations, Faculty of Veterinary Medicine, University of Liege, Belgium.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Inhalation
Airway Resistance / drug effects
Bronchoconstriction / drug effects
Cattle / physiology*
Heart Rate / drug effects
Infusions, Intravenous / veterinary
Lung / drug effects*,  physiology
Lung Compliance / drug effects
Pulmonary Wedge Pressure / drug effects
Respiration / drug effects
Respiratory Function Tests / veterinary
Serotonin / administration & dosage,  pharmacology*
Vasoconstriction / drug effects
Reg. No./Substance:
0/Aerosols; 50-67-9/Serotonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Use of computerized interactive morphometry in the diagnosis of mammary adenoma and adenocarcinoma i...
Next Document:  Clinical and metabolic findings in dogs with chronic renal failure fed two diets.