| Effect of intravenous adrenaline on electrocardiogram, blood pressure, and serum potassium. | |
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MedLine Citation:
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PMID: 6821616 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Increased catecholamines after myocardial infarction may contribute to the development of arrhythmias. We have infused adrenaline intravenously in nine normal volunteers to levels similar to those seen after myocardial infarction. Adrenaline caused an increase in systolic blood pressure, a decrease in diastolic blood pressure, and an increase in heart rate. Adrenaline also produced a decrease in T wave amplitude and an increase in the QTc interval. The serum potassium fell dramatically during the adrenaline infusion from a control value of 4.06 mmol/l to 3.22 mmol/l. Hypokalaemia after myocardial infarction is associated with an increased incidence of ventricular arrhythmias. Thus, circulating adrenaline may increase the frequency of arrhythmias both directly via changes in ventricular repolarisation and indirectly via adrenaline induced hypokalaemia. |
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Authors:
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A D Struthers; J L Reid; R Whitesmith; J C Rodger |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British heart journal Volume: 49 ISSN: 0007-0769 ISO Abbreviation: Br Heart J Publication Date: 1983 Jan |
Date Detail:
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Created Date: 1983-03-24 Completed Date: 1983-03-24 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0370634 Medline TA: Br Heart J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 90-3 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure / drug effects Electrocardiography Epinephrine / blood, pharmacology* Heart / drug effects*, physiopathology Hemodynamics / drug effects* Humans Male Myocardial Infarction / physiopathology Potassium / blood* |
| Chemical | |
Reg. No./Substance:
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51-43-4/Epinephrine; 7440-09-7/Potassium |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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