Document Detail

Effect of intravenous administration of lactated Ringer's solution or hetastarch for the treatment of isoflurane-induced hypotension in dogs.
MedLine Citation:
PMID:  19878017     Owner:  NLM     Status:  In-Process    
OBJECTIVE: To determine the effect of IV administration of crystalloid (lactated Ringer's solution [LRS]) or colloid (hetastarch) fluid on isoflurane-induced hypotension in dogs. ANIMALS: 6 healthy Beagles. PROCEDURES: On 3 occasions, each dog was anesthetized with propofol and isoflurane and instrumented with a thermodilution catheter (pulmonary artery). Following baseline assessments of hemodynamic variables, end-tidal isoflurane concentration was increased to achieve systolic arterial blood pressure (SABP) of 80 mm Hg. At that time (0 minutes), 1 of 3 IV treatments (no fluid, LRS [80 mL/kg/h], or hetastarch [80 mL/kg/h]) was initiated. Fluid administration continued until SABP was within 10% of baseline or to a maximum volume of 80 mL/kg (LRS) or 40 mL/kg (hetastarch). Hemodynamic variables were measured at intervals (0 through 120 minutes and additionally at 150 and 180 minutes in LRS- or hetastarch-treated dogs). Several clinicopathologic variables including total protein concentration, PCV, colloid osmotic pressure, and viscosity of blood were assessed at baseline and intervals thereafter (0 through 120 minutes). RESULTS: Administration of 80 mL of LRS/kg did not increase SABP in any dog, whereas administration of <or= 40 mL of hetastarch/kg increased SABP in 4 of 6 dogs. Fluid administration increased cardiac index and decreased systemic vascular resistance. Compared with hetastarch treatment, administration of LRS decreased blood viscosity. Treatment with LRS decreased PCV and total protein concentration, whereas treatment with hetastarch increased colloid osmotic pressure. CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that IV administration of hetastarch rather than LRS is recommended for the treatment of isoflurane-induced hypotension in dogs.
Turi K Aarnes; Richard M Bednarski; Phillip Lerche; John A E Hubbell; William W Muir
Related Documents :
10422937 - Sevoflurane increases lumbar cerebrospinal fluid pressure in normocapnic patients under...
12064177 - Recent advances in inhalation anesthesia.
8547547 - Isoflurane versus sodium nitroprusside for the control of proximal hypertension during ...
2800987 - Effects of isoflurane on feline intestinal blood flow during hemorrhage-induced hypovol...
7202607 - Ventilatory dysfunction and respiratory rehabilitation in post-traumatic quadriplegia.
12814447 - The effect of motilin on the rectum in healthy volunteers.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of veterinary research     Volume:  70     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1345-53     Citation Subset:  IM    
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Comparison of recovery from anesthesia with isoflurane, sevoflurane, or desflurane in healthy dogs.
Next Document:  Changes in growth of the hoof wall and hoof morphology in response to regular periods of trotting ex...