Document Detail


Effect of intravenous L-alanine administration on plasma glucose, insulin and glucagon, blood pyruvate, lactate and beta-hydroxybutyrate concentrations in newborn infants. Study in term and preterm newborn infants.
MedLine Citation:
PMID:  654907     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ten term and eleven preterm newborn infants with appropriate weights for their gestational age were infused for one minute with L-alanine (150 mg/kg) at the age of 29 to 76 hours (mean 48 hours) and circulating levels of glucose, lactate, pyruvate, D-betahydroxybutyrate (D-BOHB), insulin and glucagon were monitored. Plasma glucose concentrations increased from 2.7 +/- 0.16 (mean +/- S.E.M.) to 3.7 +/- 0.2 mmol/l after 50 min (p less than 0.01) in term infants. In preterm infants, after an initial decrease of the glucose level from 3.1 +/- 0.16 to 2.6 +/- 0.16 mmol/l (p less than 0.05), it returned to the baseline level at 50 min: 3.0 +/- 0.2 mmol/l. The blood concentration of D-BOHB decreased in term infants from 192 +/- 37 to 112 + 6 micrometer/l (p less than 0.01) after 40 min. In preterms, its decrease was not significant (p greater than 0.05). Plasma glucagon level rose from 53 +/- 5 to 70 +/- 8 pmol/l after ten minutes (p less than 0.01) in terms infants and from 61 +/- 6 to 75 +/- 9 after 20 min (p less than 0.01) in preterm infants. There were no significant changes in plasma insulin concentrations in either group. Forty minutes after L-alanine infusion, I/G ratios were lower in preterm infants (1.26 +/- 0.14) than in term infants (1.71 +/- 0.25) (p less than 0.01). There was no relationship between the glycemic responses to L-alanine and the basal levels of D-BOHB. The data suggest that the glycemic effect of L-alanine infusion and circulating glucagon depends upon a specific stage in maturation. The antiketogenic effect of L-alanine infusion is observed in term infants as in adults.
Authors:
L Sann; A Ruitton; M Mathieu; J Bourgeois; J Genoud
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta paediatrica Scandinavica     Volume:  67     ISSN:  0001-656X     ISO Abbreviation:  Acta Paediatr Scand     Publication Date:  1978 May 
Date Detail:
Created Date:  1978-07-15     Completed Date:  1978-07-15     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0000211     Medline TA:  Acta Paediatr Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  297-302     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alanine / administration & dosage,  pharmacology*
Blood Glucose* / analysis
Glucagon / blood*
Humans
Hydroxybutyrates / blood*
Infant, Low Birth Weight
Infant, Newborn*
Infant, Premature
Insulin / blood*
Lactates / blood*
Pyruvates / blood*
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Hydroxybutyrates; 0/Lactates; 0/Pyruvates; 11061-68-0/Insulin; 56-41-7/Alanine; 9007-92-5/Glucagon

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