| Effect of intraoperative intracameral 2% hydroxypropyl methylcellulose viscoelastic during trabeculectomy. | |
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MedLine Citation:
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PMID: 16156143 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVE: To evaluate the effect of intraoperative intracameral injection of 2% hydroxypropyl methylcellulose (HPMC) on anterior chamber depth and intraocular pressure (IOP) following trabeculectomy in eyes with uncontrolled primary open-angle glaucoma in a prospective randomized manner. PATIENTS AND METHODS: Thirty consecutive eyes with primary open-angle glaucoma scheduled for trabeculectomy were randomized to conventional trabeculectomy without HPMC injection (group I; n = 15) or to intracameral injection of 2% HPMC during trabeculectomy (group II; n = 15). All patients were observed serially on days 1, 3, 5, 7, and 14 and months 1, 3, and 6 postoperatively. The main outcome measure was restoration of anterior chamber depth to preoperative level with IOP of less than 21 mm Hg with no additional antiglaucoma medication or surgery. RESULTS: The anterior chamber depth decreased from 2.5 +/- 0.53 to 1.5 +/- 0.94 mm on postoperative day 1 in group I and increased slightly from 2.4 +/- 0.43 to 2.5 +/- 0.36 mm on postoperative day 1 in group II (P = .04). Overall, the IOP decreased to 5.0 +/- 2.8 mm Hg in group I (87% reduction) and 9.0 +/- 4.6 mm Hg in group II (70% reduction). Two eyes developed postoperative flat anterior chamber and related complications in group I, whereas none of the eyes in group II developed such complications. CONCLUSIONS: Intracameral injection of 2% HPMC during trabeculectomy helps to maintain anterior chamber depth and reduces incidence of complications related to shallow anterior chamber depth following trabeculectomy. |
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Authors:
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Harish C Agarwal; V K Anuradha; J S Titiyal; Viney Gupta |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye Volume: 36 ISSN: 1542-8877 ISO Abbreviation: Ophthalmic Surg Lasers Imaging Publication Date: 2005 Jul-Aug |
Date Detail:
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Created Date: 2005-09-13 Completed Date: 2005-10-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101155780 Medline TA: Ophthalmic Surg Lasers Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 280-5 Citation Subset: IM |
Affiliation:
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Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All-India Institute of Medical Sciences, Ansari Nagar, New Delhi, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Anterior Chamber / drug effects* Female Glaucoma, Open-Angle / surgery* Humans Injections Intraocular Pressure / drug effects Intraoperative Care Male Methylcellulose / administration & dosage, analogs & derivatives* Middle Aged Ophthalmic Solutions / administration & dosage* Postoperative Complications Prospective Studies Trabeculectomy / methods* |
| Chemical | |
Reg. No./Substance:
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0/Ophthalmic Solutions; 8063-82-9/hypromellose; 9004-67-5/Methylcellulose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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