Document Detail

Effect of intraoperative acetated Ringer's solution with 1% glucose on glucose and protein metabolism.
MedLine Citation:
PMID:  20300778     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate the effects of the intraoperative administration of Ringer's solution with 1% glucose on the metabolism of glucose, lipid and muscle protein during surgery. METHODS: Thirty-one adult patients, American Society of Anesthesiologists physical status I or II, undergoing elective otorhinolaryngeal, head and neck surgeries were randomly assigned to one of two patient groups: those receiving acetated Ringer's solution with 1% glucose (Group G) or those receiving acetated Ringer's solution without glucose (Group R) throughout the surgical procedure. Plasma glucose was measured at anesthetic induction (T0), artery 1 h (T1), 2 h (T2), 3 h after anesthetic induction (T3) and at the end of surgery (T4). Plasma ketone bodies, insulin and 3-methylhistidine were measured at T0 and T4. RESULTS: The intravenous infusion for patients in Group G and R was 6.1 + or - 0.8 and 6.3 + or - 1.7 ml/kg/h, respectively, with Group G patients receiving a dose of 4.1 g/h glucose. Plasma glucose levels were significantly higher in Group G than in Group R patients at T1, T2, T3 and T4; however, plasma glucose remained <150 mg/dl in both groups. The plasma concentration of ketone bodies was significantly higher (P < 0.05) in Group R than in Group G patients at T4. Changes in plasma 3-methylhistidine concentration was significantly lower in Group G than in Group R patients. These results indicate that acetated Ringer's solution with 1% glucose decreased protein catabolism without hyperglycemia among the Group G patients. CONCLUSION: The infusion of a small dose of glucose (1%) during minor otorhinolaryngeal, head and neck surgeries may suppress protein catabolism without hyperglycemia and hypoglycemia.
Kazumasa Yamasaki; Yoshimi Inagaki; Shinsuke Mochida; Kazumi Funaki; Shunsaku Takahashi; Seiji Sakamoto
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2010-03-19
Journal Detail:
Title:  Journal of anesthesia     Volume:  24     ISSN:  1438-8359     ISO Abbreviation:  J Anesth     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-14     Completed Date:  2010-09-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8905667     Medline TA:  J Anesth     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  426-31     Citation Subset:  IM    
Department of Anesthesiology and Critical Care Medicine, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago 683-8504, Japan.
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MeSH Terms
Blood Glucose / metabolism
Glucose / administration & dosage,  metabolism*,  pharmacology*
Hemodynamics / physiology
Insulin / blood
Intraoperative Care*
Isotonic Solutions*
Ketone Bodies / blood
Methylhistidines / blood
Middle Aged
Monitoring, Intraoperative
Otorhinolaryngologic Surgical Procedures
Prospective Studies
Proteins / metabolism*
Reg. No./Substance:
0/Blood Glucose; 0/Isotonic Solutions; 0/Ketone Bodies; 0/Methylhistidines; 0/Proteins; 11061-68-0/Insulin; 368-16-1/3-methylhistidine; 50-99-7/Glucose; 8026-10-6/Ringer's solution

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