| Effect of intranasal immunization with inactivated avian influenza virus on local and systemic immune responses in ducks. | |
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MedLine Citation:
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PMID: 22499863 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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To evaluate the effects of co-administration of inactivated avian influenza H9N2 virus and adjuvants in waterfowls, 10-d-old ducks were immunized intranasally with inactivated avian influenza virus (IAIV) combined with CpG DNA and sodium cholate. Immunoglobulin A and IgG antibody levels in throat and tracheal tissues increased significantly, as did specific IgA and IgG antibody levels in the serum after intranasal immunization with IAIV combined with CpG DNA and sodium cholate, compared with immunization with IAIV only. Furthermore, enhanced hemagglutination inhibition titers were also detected in serum samples taken between the third and seventh weeks after immunization with IAIV and both adjuvants compared with IAIV alone. The expression of IL-2 and IL-6 in tracheal and lung tissues increased significantly in the early period after booster immunization. However, the enhancement induced by a single adjuvant was insignificant, and no significant change was detected in the antibody titers or cytokine levels between the ducks that received IAIV alone or saline. In the viral challenge study, prior administration of both CpG DNA and sodium cholate with IAIV reduced the viral titers in the oropharynx and cloaca swabs. Our study suggests that the combination of CpG DNA and sodium cholate could be beneficial to immunization with inactivated H9N2 virus by enhancing the local and systemic immune responses. |
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Authors:
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H Kang; H Wang; Q Yu; Q Yang |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Poultry science Volume: 91 ISSN: 0032-5791 ISO Abbreviation: Poult. Sci. Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-04-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401150 Medline TA: Poult Sci Country: United States |
Other Details:
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Languages: eng Pagination: 1074-80 Citation Subset: IM |
Affiliation:
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College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China PR. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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