| Effect of intramyocardial bone marrow cell injection on left ventricular dyssynchrony and global strain. | |
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MedLine Citation:
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PMID: 18198204 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the effect of bone marrow cell injection on global strain and left ventricular (LV) dyssynchrony. METHODS: In 14 patients with severe postinfarction heart failure, 93 (14) x 10(6) autologous bone marrow cells were percutaneously injected in the infarction border zone. LV ejection fraction (LVEF), LV dyssynchrony and echocardiographic global strain were assessed at baseline and 3 months in patients and in a non-randomised control group of 10 patients with a history of infarction who developed heart failure and were treated medically. RESULTS: No periprocedural complications occurred during bone marrow cell injection. At 3 months mean (SD) LVEF increased from 23 (8)% to 27 (9)% (p = 0.02) and global strain improved from -7.7 (4.7)% to -8.5 (4.9)% (p = 0.04). In patients with > or =5% improvement in LVEF after bone marrow cell injection, global strain improved from -8.7 (4.6)% to -10.6 (4.5)% (p<0.01). Global strain remained unchanged in patients with <5% improvement in LVEF (-6.6 (4.9)% vs -6.4 (4.5)%, p = NS). The relation between the increase in LVEF and improvement in global strain was significant (r = 0.84, p<0.01). In patients with > or =5% improvement in LVEF, LV dyssynchrony decreased from 173 (64) ms to 116 (64) ms (p = 0.01). In patients with <5% improvement in LVEF, LV dyssynchrony remained unchanged (155 (67) ms vs 177 (81) ms, p = NS). The correlation between improvement in LVEF and reduction in LV dyssynchrony was good (r = -0.77, p<0.01). In the control group, LVEF, global strain and LV dyssynchrony did not improve. CONCLUSIONS: Bone marrow cell injection improves LVEF in patients with severe postinfarction heart failure. The improvement in LVEF was related to reduced LV dyssynchrony and increased global strain. |
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Authors:
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J van Ramshorst; D E Atsma; S L M A Beeres; S A Mollema; N Ajmone Marsan; E R Holman; E E van der Wall; M J Schalij; J J Bax |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-01-15 |
Journal Detail:
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Title: Heart (British Cardiac Society) Volume: 95 ISSN: 1468-201X ISO Abbreviation: Heart Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2008-12-25 Completed Date: 2009-03-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9602087 Medline TA: Heart Country: England |
Other Details:
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Languages: eng Pagination: 119-24 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiology, Leiden University Medical Centre, Leiden, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Bone Marrow Transplantation / methods* Echocardiography Epidemiologic Methods Female Heart Failure / etiology, therapy* Humans Leukocytes, Mononuclear / transplantation* Male Middle Aged Myocardial Infarction / complications, surgery* Stroke Volume / physiology Tomography, Emission-Computed, Single-Photon Ventricular Dysfunction, Left / physiopathology, surgery* |
| Comments/Corrections | |
Comment In:
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Heart. 2009 Feb;95(2):98-9
[PMID:
19001002
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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