Document Detail

Effect of intraluminal pressure on the intimal thickening in injured rabbit carotid arteries in an organ-culture system.
MedLine Citation:
PMID:  9276776     Owner:  NLM     Status:  MEDLINE    
We developed an organ culture system in order to examine the effect of intraluminal pressure on intimal thickening in injured arteries. After endothelial denudation, an excised rabbit common carotid artery was incubated at 37 degrees C in a glass bottle perfused with Dulbecco's modified Eagle medium containing 10% fetal calf serum at a constant flow rate of 6 ml/h at various static pressure of 60, 95, 130, 165, or 200 cmH2O. Intimal thickening, which consisted of smooth muscle cells and extracellular matrix, increased in a time- and pressure-dependent manner up to 130 cmH2O. Excessive pressured (165 and 200 cmH2O), however, caused necrosis in the media. These results suggest that a rise in intraluminal pressure accelerates intimal thickening in injured arteries.
H Horiuchi; M Yokode; K Ishii; M Cho; S Hara; A Sakai; K Kanai; T Tsukada; T Kita
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Japanese circulation journal     Volume:  61     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-09-30     Completed Date:  1997-09-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  704-8     Citation Subset:  IM    
Department of Geriatric Medicine, Kyoto University Faculty of Medicine, Japan.
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MeSH Terms
Blood Pressure*
Carotid Artery Injuries
Carotid Artery, Common / pathology*
Microscopy, Electron
Organ Culture Techniques
Tunica Intima / pathology*
Tunica Media / pathology

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